Estrogens play a fundamental role in the development and normal physiological function of multiple tissue systems and have been implicated in the ontogeny of cancers. The biological effects of estrogens are classically mediated via interaction with cognate nuclear receptors. The relative expression of ER subtypes/variants varies between cells within different tissues and this alters the respons...

Estrogen receptors at the plasma membrane and cytoplasm have been difficult to detect in breast cancer specimens. New imaging approaches are needed to determine the percentage of cancers expressing extranuclear estrogen receptors and their impact on cancer biology and treatment.

Several observations suggest that sex steroids might participate in steady state regulation of B lymphopoiesis. B cell precursors decline dramatically in bone marrow of pregnant or estrogen-treated mice. Reciprocally, the same cell populations are increased in hypogonadal mice or male castrates. Estrogen treatment of hypogonadal mice reduced precursors to normal. However, questions remain about...

Glucocorticoids induce ovalbumin and conalbumin mRNA in oviducts from chicks withdrawn from prior estrogen treatment. The magnitude and the kinetics of the responses obtained, either in vivo or in vitro, are comparable to those obtained with estrogen or progesterone. With cultured oviducts, 1 nM dexamethasone is sufficient for half-maximal accumulation of nuclear receptors and partial induction...

In non-human primates, the oviduct undergoes dramatic, hormonally regulated changes in morphological structure. In spayed animals, the epithelium is undifferentiated, and estro­ gen treatment can stimulate differentiation to a fully ciliated and secretory state. This state can be maintained indefinitely by estrogen, but if progestin treatment is initiated the epithelium will atrophy, dedifferen...

BACKGROUND In the mouse uterus, pregnancy is accompanied by changes in tachykinin and tachykinin receptor gene expression and in the uterotonic effects of endogenous tachykinins. In this study we have investigated whether changes in tachykinin expression and responses are a result of changes in ovarian steroid levels. METHODS We quantified the mRNAs of tachykinins and tachykinin receptors in ...

objective(s): the present study aims at examining the motor coordination performance, serum and cerebellar estrogen, as well as erβ levels, of ovariectomized rats (as menopausal model) following regular exercise. materials and methods:ten female sprague dawley ratsaged 12 weeks old were randomly divided into two groups; all of which underwent ovariectomy. the first group was treated with regula...