Research on the extraction of chemical components Dengen (Dillenia serrata Thumb) leaves using MAE (microwave-assisted extraction) method and activity as an antioxidant toxicity test has been carried out. This study aimed to extract ethanol leaves. The were extracted by obtained with a yield 47%. was partitioned n-hexane solvents yields 5% (n-hexane) 65% (ethanol). leave identified phytochemica...

Bottom-up synthesis of cubosomes is more energetically favourable than top-down approaches. However, bottom-up methods often rely on organic solvents such as ethanol diluents, and lead to concurrent formation liposomes. We propose using non-toxic diluents honey, glycerol lactic acid for cubosome synthesis. Cubosomes were prepared solutions phytantriol in a range including choline chloride-glyce...

Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...

The relationship between bulk membrane fluidizing effect of ethanol and its toxicity due to oxidative stress is still unknown. To elucidate this issue, membrane fluidity of primary rat hepatocytes was studied by measuring order parameter after inhibition of ethanol-induced oxidative stress. We showed that pretreating cells with either 4-methyl-pyrazole (to inhibit ethanol metabolism), thiourea ...

Ethanol-induced neuronal death during a sensitive period of brain development is considered one of the significant causes of fetal alcohol spectrum disorders (FASD). In rodent models, ethanol triggers robust apoptotic neurodegeneration during a period of active synaptogenesis that occurs around the first two postnatal weeks, equivalent to the third trimester in human fetuses. The ethanol-induce...

Background: Calotropis gigantea of family Asclepiadaceae, is traditionally used in ayurveda for its anti-helminthic, anti-pyretic, and anti-malarial activities. The present study was designed to investigate the sub-acute toxic effects of ethanol and methanol extract of Calotropis gigantea latex in mouse model using haematology, serum biochemistry and histopathological changes as toxicity indice...

A series of column studies, using site-specific soil and groundwater, were conducted to determine the feasibility of biologically active zone enhancement (BAZE) process for reductive biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater. This treatability study examined the use of four amendments (acetate, ethanol, soluble starch, and acetate plus ammonium), which se...

background: diabetes mellitus is an alarming life style disease in the modern world. exploitation of the anti-diabetic drugs for the amelioration of diabetes and associated life style diseases has become an imperative concern. in this milieu, this study was designed to explore the plausible effects of metformin intervention on hepatic and renal functions in a rat model of alcoholic liver diseas...

Transforming growth factor (TGF) beta1 regulates cell migration of non-neural cells. Hence, two hypotheses were tested: (i) that TGFbeta1 affects cell migration and the expression of associated adhesion proteins in developing cortex; and (ii) that these effects are antagonized by ethanol. The effects of TGFbeta1 (2.5-40 ng/ml) and ethanol (400 mg/dl) on cell migration were examined in organotyp...

Article history: Received on: 02/02/2013 Revised on: 04/03/2013 Accepted on: 15/03/2013 Available online: 30/03/2013 The present study was designed to evaluate the antioxidant activity of Livomap on ethanol induced hepatotoxicity in albino wistar rats. A total of 30 rats were divided into five groups of six rats in each group. Group 1 served as normal control, Group 2 normal rat + livomap (50mg...