نتایج جستجو برای: ethanol toxicity

تعداد نتایج: 223361  

Journal: :Alcohol and alcoholism 2011
Frédéric Lallemand Roberta J Ward Philippe De Witte Paul Verbanck

AIMS The effect of 'binge drinking' coupled or not with chronic nicotine administration on nucleus accumbens (NAc) glutamate, arginine, taurine and hydroxyl radical levels has been investigated in these present studies. METHODS AND RESULTS Ethanol, 2 or 3 g/kg, has been administered to male or female adult rats in a 'binge-type' regime for 3 weeks, +/- nicotine, and changes in glutamate, argi...

2011
A.Pandi Selvi S. Rajkumar G. Sandhya

Morinda citrifolia is a member of the Rubiaceae. It is a Shrub or compacted to twisted small tree up to 8 m high with square stems and large stipules between nodes and petioles. Leaves are opposite, petiolate, glossy, mostly ovate, 15-35 cm long. Flowers white, up to 15 mm long, with a tubular corolla and 5 spreading lobes, the flowers borne on a globose syncarp. Fruit a large fleshy syncarp up...

2015
Giovana Brolese Paula Lunardi Daniela F. de Souza Fernanda M. Lopes Marina C. Leite Carlos-Alberto Gonçalves

The developing brain is vulnerable to the effects of ethanol. Glutamate is the main mediator of excitatory signals in the brain and is probably involved in most aspects of normal brain function during development. The aim of this study was to investigate vulnerability to and the impact of ethanol toxicity on glutamate uptake signaling in adolescent rats after moderate pre and postnatal ethanol ...

Journal: :Molecular pharmacology 1998
K Sakurai A I Cederbaum

Iron can potentiate the toxicity of ethanol. Ethanol increases the content of cytochrome P450 2E1 (CYP2E1), which generates reactive oxygen species, and transition metals such as iron are powerful catalysts of hydroxyl radical formation and lipid peroxidation. Experiments were carried out to attempt to link CYP2E1, iron, and oxidative stress as a potential mechanism by which iron increases etha...

B. Lau Chik Chuon L. Yu Ren S. Parasuraman* S. Wong Kah Yee

Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...

Journal: :jundishapur journal of natural pharmaceutical products 0
heibatullah kalantari department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran ali asghar hemmati department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran mehdi goudarzi department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran hossein forouzandeh department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; iranian blood transfusion organization (ibto), shiraz, ir iran; department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-9379873029, fax: +98-7152247777 mojtaba kalantar department of pharmacology and toxicology, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran nasrin aghel department of pharmacogenosy, pharmacy school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

background t-2 toxin is a mycotoxin, exposure to which causes dermal and systemic toxicity. crataegus pontica (a member of the rosaceous family) is a small tree with caduceus foliage that is widely distributed throughout the western and central areas of iran. objectives this study was performed to examine the healing effects of creams prepared using crataegus pontica leaf extract on dermal toxi...

2004
Tamie Nakajima Yuji Kamijo Naoki Tanaka Eiko Sugiyama Eiji Tanaka Kendo Kiyosawa Yoshimitsu Fukushima Jeffrey M. Peters Frank J. Gonzalez Toshifumi Aoyama

The mechanisms underlying alcoholic liver disease are not completely understood, but lipid accumulation seems to be central to the cause of this disease. The peroxisome proliferatoractivated receptor (PPAR ) plays an important role in the control of lipid homeostasis, metabolism of bioactive molecules, and modulation of inflammatory responses. To investigate the roles of PPAR in alcoholic liver...

2015
Yongke Lu Arthur I. Cederbaum Natalia Osna Kusum Kharbanda

Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived proteins and cellular organelles. The effects of ethanol on autophagy are complex but recent studies have shown that autophagy serves a protective function against ethanol-induced liver injury. Autophagy was found to also be protective against CYP2E1-dependent toxicity in vitro in HepG2 cells which express C...

Journal: :Environmental Health Perspectives 1977
E L Krawitt

Effects of ethanol on the gastrointestinal tract are reviewed, and an overview of possible mechanisms of ethanol damage to the alimentary tract is presented. Ethanol toxicity most commonly results in metabsorption. Mechanisms contributing to ethanol-induced calcium malabsorption are considered in detail as a prototype for problems encountered in evaluating effects of toxicants on intestinal fun...

2014
Zilong Liu Yongping Liu Rui Gao Haixia Li Tiffany Dunn Ping Wu Robert G. Smith Partha S. Sarkar Xiang Fang

Alcohol intoxication results in neuronal apoptosis, neurodegeneration and manifest with impaired balance, loss of muscle coordination and behavioral changes. One of the early events of alcohol intoxication is mitochondrial (Mt) dysfunction and disruption of intracellular redox homeostasis. The mechanisms by which alcohol causes Mt dysfunction, disrupts cellular redox homeostasis and triggers ne...

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