In the present study, ribociclib-loaded nanosponges (RCNs) composed of ethylcellulose and polyvinyl alcohol were developed using an emulsion-solvent evaporation method. Preliminary evaluations RCNs (RCN1 to RCN7) performed in terms size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), drug loading (DL), which allowed us select optimized formulation. RCN3 was selecte...

This study describes the methodology for the development of a validated in-vitro in-vivo correlation (IVIVC) for metoprolol tartrate modified release dosage forms with distinctive release rate characteristics. Modified release dosage forms were formulated by microencapsulation of metoprolol tartrate into different amounts of ethylcellulose by non-solvent addition technique. Then in-vitro and in...

The aim of present study was to formulate and evaluate the loxoprofen loaded Sustained release microspheres by emulsion solvent evaporation technique. Ethylcellulose, a biocompatible polymer is used as the retardant material. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres w...

The interactions between natural and synthetic materials and blood components are analyzed with emphasis on the interdependence between biomaterials research and development and ultimate applications. Two new synthetic polymers, perfluorobutyryl ethylcellulose and polyalkylsulfone, that combine desirable blood compatibility and gas-to-blood transfer rates are discussed in terms of their potenti...

Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis of their physical char...