−To obtain highly purified naphthalene, a column crystallizer was employed and operated in the continuous multistage countercurrent fractional mode. The principles and characteristics of the process are introduced. A large amount of experimental work has been done on the crystallization process in a D=50 mm×1,350 mm column. The effects of operation conditions including the composition of feed, ...

Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...

New resolving bases for ibuprofen 1 and mandelic acid 2 were studied and qualified by their binary phase diagrams of the corresponding salts. It was shown that analysis of the binary phase diagrams gives a good prediction for a resolution process. A comparison of resolving bases revealed that (S)-phenylglycinol (S)-7 is the best resolving base for ibuprofen 1. By the same procedure, various res...

In pursuit of understanding structure–property relationships for the melting point depression binary eutectic mixtures, influence anion on solid–liquid (S–L) phase behavior was explored mixtures glutaric acid + tetraethylammonium chloride, bromide, and iodide. A detailed experimental evaluation S–L revealed that is shifted toward lower temperatures higher salt contents upon decreasing ionic rad...

A PLE-SPE extraction process for the anthocyanins from Jabuticaba wastes was developed using an eutectic mixture, this acting simultaneously as solvent and stabilizing agent.

Thermal Energy Storage using phase change materials has become an interesting area of energy research because of its high energy storage density, isothermal nature of storage process and small volume changes. There are wide ranges of phase change materials available commercially. This work deals with paraffin and Palmitic acid eutectic mixture in three different proportions as phase change mate...

We report on the formation of eutectic mixtures of ibuprofen using two different polymers together with investigations on the in-vitro release of ibuprofen from drug-in-adhesive layers. Ibuprofen, literature melting point (m.p.) = 73.5-76.5°C, was tested together with Pluronic F127, literature m.p. = 54.4-60.5°C, and polyethylene glycol 1000 (PEG 1000), literature m.p. = 37-40.9°C, as second co...