OBJECTIVE(S) Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...

A nickel-based single-crystal superalloy was employed to investigate the preferred growth orientation behavior of the (γ + γ') eutectic and the effect of these orientations on the segregation behavior. A novel solidification model for the eutectic island was proposed. At the beginning of the eutectic island's crystallization, the core directly formed from the liquid by the eutectic reaction, an...

A rapid and direct liquid chromatographic (LC) technique is described for the determination of a eutectic mixture of diphenyl oxide and biphenyl such as Dowtherm A thermal heating fluid (THF) in oleochemicals and palm olein. Analysis is performed with an RP-18 column with fluorescence detection (excitation at 247 nm and emission at 310 nm). The isocratic mobile phase (1.0 mL/min) consists of me...

Magnesium alloys are attracting great interest from the automotive industry because of the potential for weight reduction. An AZ91D cast alloy was studied in the current work to understand the effect of heat treatment on the microstructure and dynamic compressive properties. The selected heat treatments include solution treatment (T4) and solution treatment followed by aging (T6). The as-cast a...

Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Bibliographi...

Electroneurography (ENoG) is an electrodiagnostic procedure used to evaluate facial nerve deficit. A problem with application, however, is pain. Several studies have demonstrated that topical application of the eutectic mixture of lidocaine and prilocaine has an anesthetic effect on superficial and deep tissues. The present study was intended to determine if successful anesthesia of the trigemi...

Freeze casting for Al2O3 was accomplished at room temperature with nonaqueous sublimable vehicles in the naphthalene– camphor eutectic system with a eutectic temperature of 31°C. A fully dense sintered body (>99.5% of theoretical density (T.D.)) was obtained with a eutectic composition vehicle, whereas at most 90% T.D. was obtained with an off-eutectic (i.e., hypoor hypereutectic) composition v...