background: the aim of this study was to evaluate the reduction in excision cavity volume (ecv) during the whole breast radiotherapy (wbrt). the delineating of reduced cavity volume on secondary ct (computed tomography) might decrease the field size of boost plan. materials and methods: twenty patients were treated having breast conservative surgery. at first, primary ct simulation (ct-1) was d...

Background: The aim of this study was to evaluate the reduction in excision cavity volume (ECV) during the whole breast radiotherapy (WBRT). The delineating of reduced cavity volume on secondary CT (computed tomography) might decrease the field size of boost plan. Materials and Methods: Twenty patients were treated having breast conservative surgery. At first, primary CT simulation (CT-1) was d...

Background Extracellular volume fraction cardiac magnetic resonance (ECV-CMR) enables quantitative myocardial tissue characterization. Increased myocardial ECV is correlated to myocardial fibrosis, inversely related to the left ventricle ejection fraction (LVEF), and an independent predictor of mortality. Dilated cardiomyopathy (DCM) is characterized by decreased LVEF and increased LV end-diast...

Background T1 mapping and extracellular volume (ECV) imaging are promising tools to quantify increased extracellular distribution volume of contrast media after myocardial damage. We evaluated the ability of ECV imaging to measure infarct size compared to late gadolinium enhancement (LGE) after acute myocardial infarction (AMI). Additionally, the amount of cellular damage was serially measured ...

BACKGROUND Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-...

Background The extracellular volume fraction (ECV) is a surrogate marker for diffuse myocardial fibrosis. ECV is calculated from preand post-contrast T1 maps and corrected for hematocrit (Hct). Current workflows are cumbersome, but an automated ECV map tool simplifies this and could promote adoption into routine clinical practice. We assessed the performance of automated ECV maps versus convent...

AIM The aim of this study was to determine the value of extracellular volume fraction (ECV) for the non-invasive assessment of diffuse myocardial fibrosis (MF) in different stages of systolic left ventricular (LV) dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy. BACKGROUND Non-invasive ECV assessment using cardiovascular magnetic resonance (CMR) T1 mapping...

AIMS To determine the optimal T1 mapping approach to assess myocardial fibrosis at 3T. METHODS AND RESULTS T1 mapping was performed at 3T using the modified look-locker-inversion sequence in 20 healthy volunteers and 20 patients with aortic stenosis (AS). Pre- and post-contrast myocardial T1, the partition coefficient (λ; ΔRmyocardium/ΔRblood, where ΔR = 1/post-contrast T1 - 1/pre-contrast T1...

This article describes data related to a research article titled "Estimation of myocardial extracellular volume fraction with cardiac CT in subjects without clinical coronary artery disease: A feasibility study", Kurita et al. (in press) [1]. Myocardial extracellular volume fraction (ECV) is an imaging biomarker that can elevate in various heart diseases. This article describes correlation betw...

Background Late gadolinium enhancement (LGE) is excellent for identifying focal lesions in the myocardium (necrosis, fibrosis), but diffuse homogeneous abnormalities are not readily detectable. Quantitative measurement of the myocardial extracellular volume (ECV) fraction using MRI has recently been validated histologically, and implemented for parametric imaging in patients. We hypothesized th...