Objective: The objective of this investigation was to formulate and evaluate effervescent pellets febuxostat achieve sustain release effect.
 Place Duration Study: APMC College Pharmaceutical education research, Department Pharmaceutics, Himatnagar-383001, between June 2019 July 2021.
 Materials Methods: gastro retentive were formulated using Sodium CMC HPMC K4M HPMCK15M as a polymer....

Spheronization of cylindrical extrudates on a rotating friction plate involves breakage and rounding. Little attention has been given to the stage quantitative modeling this process is scarce. Two simple models are compared with experimental data obtained for early stages spheronization microcrystalline cellulose/water extrudates. Tests were conducted different times (t), rotational speeds (ω),...

The present work aims to predict drug release from novel site-specific release isoniazid pellets, in USP dissolution test apparatus 3, using the response surface methodology (RSM). Site-specific release isoniazid pellets were prepared by extrusion-spheronization followed by aqueous coating of Acryl-EZE. RSM was employed for designing of the experiment, generation of mathematical models and opti...

Three processed lactose-cellulose blends of similar composition, particle size and true density were compared as direct compression excipients: one was prepared by dry granulation, one by extrusion-spheronization, and the commercial product Cellactose. Differences among their flow properties depended solely on their different sphericities. Unlike those of the other blends, Cellactose particles ...

Budesonide, a potent glucocorticoid, is used for the treatment of inflammatory bowel diseases. Current available oral formulations of budesonide have low efficacy against ulcerative colitis because of the premature drug release in the upper part of the gastrointestinal tract. In this paper a pH- and time-controlled colon-targeted pellet-based tablet of budesonide was established. Pellet cores w...