A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol...

Aim of the study was the development and validation of the psychometric properties of a six-item bi-factorial instrument for the assessment of social support (emotional and tangible support) with a population-based sample. A cross-sectional data set of N = 15,010 participants enrolled in the Gutenberg Health Study (GHS) in 2007-2012 was divided in two sub-samples. The GHS is a population-based,...

Many disorders require multi-component treatments given sequentially in time to achieve and maintain good outcomes. The development of these adaptive treatment strategies is challenging due to the large number of components and sequencing of components. We propose the use of screening experiments in which scientists screen out inactive components. Unfortunately when the goal is to construct ada...

Dynamic treatment regimes are time-varying treatments that individualize sequences of treatments to the patient. The construction of dynamic treatment regimes is challenging because a patient will be eligible for some treatment components only if he has not responded (or has responded) to other treatment components. In addition there are usually a number of potentially useful treatment componen...

A number scales have been developed to measure conspiracist ideation, but little attention has been paid to the factorial validity of these scales. We reassessed the psychometric properties of four widely-used scales, namely the Belief in Conspiracy Theories Inventory (BCTI), the Conspiracy Mentality Questionnaire (CMQ), the Generic Conspiracist Beliefs Scale (GCBS), and the One-Item Conspiracy...

In this paper we present a natural and comprehensive generalisation of the standard factorial moments (F q) analysis of a multiplicity distribution. The Generalised Factorial Moments are defined for all q in the complex plane and, as far as the negative part of its spectrum is concerned, could be useful for the study of infrared structure of the Strong Interactions Theory of high energy interac...

A novel technique for the analysis of fluorescence fluctuation experiments is introduced. Fluorescence cumulant analysis (FCA) exploits the factorial cumulants of the photon counts and resolves heterogeneous samples based on differences in brightness. A simple analytical model connects the cumulants of the photon counts with the brightness epsilon and the number of molecules N in the optical ob...

By using three-mode principal components analysis and perfect congruence analysis in conjunction, the factorial structure of the 11 correlation matrices of the Wechsler Intelligence Scale for Children-Revised was analyzed within a single framework. This allows a unified description showing both the strong similarities between the standardization samples and some small differences related to age...

State University of New York at Stony Brook 2A two-level factorial design can be uniquely represented by a polynomial indicator function. Therefore, properties of factorial designs can be studied through their indicator functions. This paper shows that indicator function is an effective tool in studying two-level factorial designs. Indicator function is used to generalize aberration criterion o...

Let S ⊆ Z. The generalized factorial function for S, denoted n!S , is introduced in accordance with theory already established by Bhargava ([4]). Along with several known theorems about these functions, a number of other issues will be explored. This Thesis is divided into 4 chapters. Chapter 1 provides the necessary definitions and offers a connection between the generalized factorial function...