Based on results of prior trials (TAGS, REGARD, RAINBOW), it seems promising to combine Ramucirumab (Ram) beyond progression (PD) with TAS-102 (trifluridine/tipiracil). The purpose RE-ExPEL is investigate the tolerability, safety and benefit Ram PD in combination advanced esophagogastric adenocarcinoma (EGA). This a multicenter, non-randomized, open-label investigator initiated pilot trial. 20 ...

Abstract Despite the decreases in temperature and permeability of oceanic plates with increasing age, hydrothermal circulation (HC) can be rejuvenated 130-Ma old Pacific plate vicinity Japan Trench, substantially affecting thermal structure remaining amount magnetization (RAM). To decipher roles HC RAM, vigor extent Trench should quantitatively evaluated. Here we numerically show that is outer-...

To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored. The existing modeling tools, however, cover only a few memory technologies, technology nodes and fabrication approaches. We present DESTINY, a tool for modeling 2D/3D memori...

Post-embryonic root growth relies on the proliferative activity of the root apical meristem (RAM), consisting, in part, of cells with juvenile characteristics (stem cells). It is generally, but erroneously held that the RAM indefinitely produces new cells throughout the lifespan of a plant, resulting in indeterminate root growth. On the contrary, convincing data, mainly from the lab of Thomas L...

BACKGROUND In order to rapidly assess nutrient intake, Food Frequency Questionnaires (FFQ) have been developed and proven to be reliable for quick, user friendly analysis in adults. However, the accuracy of these questionnaires in children has been studied to a limited extent. The aim of this study was to compare the daily calcium intake values obtained from the Rapid Assessment Method (RAM), a...

Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on intact prefrontal and hippocampal function. The goal of the present study was ...

Surface area and volume measurements were made for ram and human spermatozoa. Measurements were made using different techniques in an attempt to confirm estimates arrived at by independent methodologies. Sperm head projected surface areas were calculated from published formulae using linear micrometry measurements or were obtained directly by image analysis. Total surface areas were calculated ...

• • • • • • • • • • • .................................. . . . . . . . . . . . . ........ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..................... . . . . . . . . . . . . . . . . . . . . . . . . . . .............. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .......................................

The main aim of this paper is to construct menarcheal life-table of Nepal using sample survey data. An alternative technique for the construction such as a life-table based on models has been proposed. The construction of such a life-table describes the distribution of the waiting time for getting menarche at birth as well as some specified age or age group of girls (in years). The average expe...

This paper describes PPRAM (Parallel Processing Random Access Memory) that is an architectural framework for merged memory/logic ASSPs(Application-Speci c Standard Products). At rst, the paper discusses the serious problems that the current high-performance microprocessor-based systems are facing: memory wall, design-cost/time problem, and limits of instruction-level parallelism, and how PPRAM ...