This is a report of haemoglobin E trait in a black American family with no known Asian ancestory. The father appears to be heterozygous for both haemoglobin E and alpha-thalassaemia. The mother is normal both clinically and haematologically. These children carry Hb E trait alone. The youngest son has a normal haemoglobin pattern and appears to have alpha-thalassaemia.

A father and son, both affected by a skeletal dysplasia with severe craniofacial deformities, are reported and compared to three previously described isolated cases of the same dwarfism. The principal features are craniosynostosis, multiple lucent metaphyseal defects, flattening and anterior beaking of the vertebral bodies, and abnormal dentition. Autosomal dominant inheritance is suggested.

Maria became queen on the death of her father from a stroke in 1776 and reversed many of the changes wrought by Pombal. Apart from an isolated episode of delirium in 1781, her first symptoms of mental ill health occurred in 1788 following the deaths from smallpox of her elder son and of her daughter and husband and their infant son; Maria felt considerable guilt as she had opposed smallpox inoc...

SoDAiy, son of Mohan Chamar, of yaziwala District, Bijnor, aged 12 years, was brought to hospital about 6 p.m. on the evening of the 26th May, 1927, by his father. The father stated that the boy had climbed over a tree trunk, leaving his stick balanced against the trunk. He 'had slipped and fallen on to the stick, which had entered the anus. On examination there was no external injury on any pa...

The involvement of all five offspring of consanguinous and hypertriglyceridemic parents (first cousins) is reported. Three sons and two daughters of this family have increased triglycerides, normal cholesterol, and normal or slightly increased phospholipids. Mother and elder daughter have abnormal glucose tolerance. Father and mother are hypertensive; father had recent development of myocardial...

BACKGROUND The mitotic and meiotic behaviour of a transmitted ring Y [r(Y)] chromosome from a father to his Klinefelter syndrome (KS) son, and the mechanism of ring formation are analysed herein. To our knowledge, this is the first reported case of natural transmission of an r(Y). METHODS AND RESULTS Amplification of X chromosome polymorphisms by PCR showed that the KS was of paternal origin....

A father and son with agenesis of the corpus callosum are described. An 11-year-old boy underwent clinical examination because of poor school performance. On physical and mental examinations he was normal, except for an enlarged head. Computerized tomographic (CT) scan showed agenesis of the corpus callosum. The patient's father also had an enlarged head. Although he had never had any symptoms,...

Porokeratosis is a disorder of keratinization showing a well-defined lesion with a hyperkeratotic ridge on the border that contains the coronoid lamella. We report familial (autosomal dominant with reduced penetrance) disseminated plaque type (Mibelli's type) porokeratosis in a father and son. In the father, there were multiple horns and a large squamous cell carcinoma in a large lesion over th...

Cremation of the dead has been legal in Great Britain only since the end of the last century, when the activities of an eccentric General Practitioner in South Wales precipitated a crisis. According to Bernard Knight (1987), "this eccentric family doctor, towards the end of a colourful career, became the father of a small son named Jesus Christ Price. When the infant died, the father publically...