background: recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in wistar rats. it provided liver protection against chemical, cholestatic, and alcohol injury. resveratrol can improve glucose metabolism an...

background: despite the prevalence of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash), no treatment has been proven to be effective in these common diseases. although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy is stil...

background there are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (nafld) in different populations. however, the existing literature lacks powerful studies addressing the factors which may predict the severity of nafld. objectives in the current study, we aimed to evaluate factors independently associated with liver echogenicity in a...

background non-alcoholic fatty liver disease (nafld) is a growing diagnosed condition which causes a wide spectrum of liver disorders. there is a lot of evidence introducing nafld as a risk factor for coronary artery disease (cad) but there is substantial challenge on the independency of this correlation. conclusions according to the results of the current study, the prevalence of nafld among t...

background nonalcoholic steatohepatitis (nash) is a common liver disease that can progress to cirrhosis or hepatocellular carcinoma. it is estimated that up to 3% of the iranian population have this condition. although the pathogenesis of nash is incompletely understood, there is significant evidence pointing to the importance of insulin resistance. metformin is an oral hypoglycemic agent known...

â  â  background a substantial proportion of the mortality in patients with type 2 diabetes mellitus (t2dm) is related to non-alcoholic fatty liver disease (nafld) and its complications. insulin resistance is a major etiologic factor for the development of fatty liver. we aimed to study the prevalence of nafld among t2dm patients and its relation to insulin resistance. methods patients with t2d...

conclusions plasma opn is comparable to afp as a diagnostic marker and is related to the severity of liver involvement in hcc patients. plasma opn is of diagnostic potential value in nafld. background osteopontin (opn) is a secreted glycoprotein and is frequently associated with various tumors. objectives we sought to investigate the clinical usefulness of the level of plasma opn, compared to α...

patients and methods in the double-blind placebo study, 33 obese children with nafld from 2008 to 2009 were included. lifestyle intervention (balanced calorie diet, 1300-1800 kcal/d and physical activity) was prescribed to all. the patients were concurrently randomized to receive vitamin e 400 mg/d (n = 17)] or placebo (n = 16). results at the end of six months of therapy there was significant ...

results inter-observer agreement of the pathology scores based on nas scoring system was acceptable for steatosis, lobular inflammation, and fibrosis, but not for hepatocyte ballooning. the intra-observer agreement was acceptable in all scales, with lowest intra-class correlation observed for lobular inflammation. materials and methods the anonymous liver biopsy samples of 100 consecutive nafld...

conclusions intake of water extract of silybum marianum is a useful treatment for liver function in drug-induced fatty liver. results concentrations of hdl-c and protein decreased and activity of alt increased in tmx group compared with the control group. the sme increased protein concentration and decreased alt activity in tmx-sme group compared with the tmx group. histopathological examinatio...