Carcinogenic activity of several synthetic N-nitroso compounds was evaluated in C57BL/6J X C3HeB/FeJ F1 mice. Test substances, suspended in trioctanoin, were injected i.p. in three equal doses given on Days 1, 4, and 7 after birth and animals were held without further treatment for up to 85 weeks. Nitrosoephedrine at a total dose of 600 mg/kg induced metastasizing liver cell carcinomas in 28 of...

Previous work has demonstrated that SWR/J (SW) mice avoid phenylthiocarbamide (PTC) to a greater degree than C3HeB/FeJ mice in 48 h, two-bottle preference tests given in ascending series. The authors hypothesized, based also on previous work, that SW mice might form a conditioned taste aversion over time due to the toxic properties of PTC. We directly tested this hypothesis by attempting to con...

A metformin egy biguanid antidiabetikum, melyet a 2. típusú diabetes kezelésére alkalmaznak. Kedvezően befolyásolja az inzulinrezisztenciát, de emellett több támadásponton is csökkenti daganatsejtek onkogenetikus hatását, mérsékli oxidatív stresszt és szervezet gyulladásos reakcióit.Tanulmányunkban arra kérdésre kerestük választ szakirodalom áttekintése alapján, hogy befolyásolja-e milyen módon...

The frequency of breast cancer metastatic spread is affected by the menstrual cycle phase of its resection. Breast cancer growth, post-resection spread, and cure frequency are each modulated by the estrous cycle in C(3)HeB/FeJ mice. Tumor metastases are 2- to 3-fold more frequent when the resection is done during diestrus as compared with estrus. Tumor angiogenesis is essential for both cancer ...