The carcinogenicity of safrole following transplacental ex posure of the mouse fetus and exposure of the neonatal mouse via the mother's milk was investigated in C57BL/6J x CSHeB/ FeJ F, (hereafter called B6C3F,) mice by intragastric admin istration of the agent to pregnant and lactating C57BL/6J females. Safrole (120 ftg/g body weight per treatment) was administered to (a) pregnant mice (4 tim...

Donor T cell responses to host alloantigen are known predictors for graft-versus-host disease (GVHD); however, the effect of donor responsiveness to an inflammatory stimulus such as lipopolysaccharide (LPS) on GVHD severity has not been investigated. To examine this, we used mouse strains that differ in their sensitivity to LPS as donors in an experimental bone marrow transplant (BMT) system. L...

In this work, we study the inconsistency of EKF-based SLAM from the perspective of observability. We analytically prove that when the Jacobians of the system and measurement models are evaluated at the latest state estimates during every time step, the linearized error-state system employed in the EKF has observable subspace of dimension higher than that of the actual, nonlinear, SLAM system. A...

A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been conducted in corticosteroid-treated rats. There is need for the development of new small animal models with more selective methods of immunosuppression. This study outlines a new mouse model in whic...

Dominant mutations of transmembrane channel-like gene 1 (TMC1) cause progressive sensorineural hearing loss in humans and Beethoven (Tmc1Bth/+) mice. Here we show that Tmc1Bth/+ mice on a C3HeB/FeJ strain background have selective degeneration of inner hair cells while outer hair cells remain structurally and functionally intact. Inner hair cells primarily function as afferent sensory cells, wh...

BACKGROUND It has been hypothesized that early host-responses during TB treatment may paradoxically promote survival of persistent bacteria. We therefore evaluated whether adjunctive inhibition of tumor necrosis factor alpha (TNF-α)-a key cytokine in host responses against TB-could hasten bacterial clearance in a mouse strain that develops necrotic lesions in response to Mycobacterium tuberculo...

If the training dataset is not very large, image recognition is usually implemented with the transfer learning methods. In these methods the features are extracted using a deep convolutional neural network, which was preliminarily trained with an external very-large dataset. In this paper we consider the nonparametric classification of extracted feature vectors with the probabilistic neural net...

-The symmetry of the modulated icosahedral structure recently observed m Al~,~cu~~fej~~ is analyzed. The 12D superspace group associated with the structure is described by a pair of 6D icosahedral superspace groups, which can be identified as jF53m, P53m). Within the frame of a generalized Landau theory, the irreducible representation associated with the order parameter describing the distortio...

The efficacy of rituximab treatment in multiple sclerosis has renewed interest in the role of B cells in CNS autoimmunity. In this study, we show that B cells are the predominant MHC class II(+) subset in the naive CNS in mice, and they constitutively express proinflammatory cytokines. Incidence of experimental autoimmune encephalomyelitis induced by adoptive transfer was significantly reduced ...

BACKGROUND Bacteria can be selectively imaged in experimentally-infected animals using exogenously administered 1-(2'deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-[(125)I]-iodouracil ([(125)I]-FIAU), a nucleoside analog substrate for bacterial thymidine kinase (TK). Our goal was to use this reporter and develop non-invasive methods to detect and localize Mycobacterium tuberculosis. METHODOLOGY/P...