Despite considerable progress in understanding the pathogenesis of Mycobacterium tuberculosis (Mtb), development of new therapeutics and vaccines against it has proven difficult. This is at least in part due to the use of less than optimal models of in-vivo Mtb infection, which has precluded a study of the physiology of the pathogen in niches where it actually persists. C3HeB/FeJ (Kramnik) mice...

We consider the general class of strongly Fej er monotone map-pings and some of their basic properties. These properties are useful for a convergence theory of corresponding iterative methods which are widely used to solve convex problems. In part II the geometrical properties of these map-pings are studied. In particular the maximal of such mappings with respect to set inclusion of the images ...

Let M be a unitary matrix with eigenvalues t j , and let f be a function on the unit circle. Deene X f (M) = P f(t j). We derive exact and asymptotic for-mulae for the covariance of X f and X g with respect to the measures j(M)j 2 dM where dM is Haar measure and an irreducible character. The asymptotic results include an analysis of the Fej er kernel which may be of independent interest.

Vinyl carbamate (VC) is a suspect metabolic intermediate in ethyl carbamate (EC) carcinogenesis. In the present studies, EC and VC were evaluated for their relative abilities to induce adenomas and sister chromatid exchanges (SCEs) in lung cells of A/J, C3HeB/FeJ, and C57BL/6J strain mice. For both end points, animals were administered a single i.p. injection of the test chemical. Percentage of...

New drugs and drugs with a novel mechanism of action are desperately needed to shorten the duration of tuberculosis treatment, to prevent the emergence of drug resistance, and to treat multiple-drug-resistant strains of Mycobacterium tuberculosis. Recently, there has been renewed interest in clofazimine (CFZ). In this study, we utilized the C3HeB/FeJ mouse model, possessing highly organized, hy...

Five reciprocal cycles of subtractive hybridization using cDNA generated from fibroblasts with normal lipopolysaccharide (LPS) responsiveness (lps(n)) and from hyporesponsive (lps(d)) fibroblasts have led to the finding that caveolin-1 is expressed at markedly higher levels of mRNA in lps(d) than in lps(n) fibroblasts. Caveolin-1 message can also be readily detected via reverse transcription-PC...