Four new farnesyl hydroxybenzoic acid derivatives, kuhistanols E-H (1-4), were isolated from the roots of the Uzbekistan medicinal plant Ferula kuhistanica. The structures of the new compounds were elucidated based on spectroscopic and chemical evidence.

UNLABELLED BACKGROUND The biological importance of members of genus Ferula promoted us to investigate the leaves of Ferula vesceritensis Coss et Dur. (endemic plant) previously not investigated. This study presents the chemical composition and antibacterial activities of the hydrodistilled oils. RESULTS Volatile components of the leaves of F. vesceritensis have been studied by gas chromato...

Xinjiang, a region of high salinity and drought, is a host to many arid and semi-arid plants. Many of these plants including Ferula spp. have indigenous pharmaceutical histories. As many of the medicinal properties of plants are in tandem with the associated microorganisms residing within the plant tissues, it is advisable to explore the endophytic potential of such plants. In the present study...

The germination of Ferula ovina seeds faces certain problems. The present research was designed to study the promotion of the germination of Ferula ovina seeds by moist-chilling and GA3 applications. The results showed that Ferula ovina seeds display an endogenous dormancy that can be released by moist-chilling treatment for a certain period. In this respect, the best treatment was moist-chilli...

Ferula turcica and latialata are two novel endemic species discovered in the Konya Kırşehir provinces of central Anatolian region Türkiye. These new described by morphological, ecological, carpological, phytochemical characteristics phylogenetic analysis. F. morphologically distinct from szowitsiana their habit, stalk terminal umbella, mericarp size, as well profile secondary metabolite markers...

Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identi...

The article analysis the species composition of entomofauna Kuhistan ferula (Ferula kuhistanica) in different parts Zarafshan ridge. study revealed 115 insects belonging to 92 genera, 48 families, and eight orders. identified belong following orders: Thysanoptera (1 species), Neuroptera (3 Homoptera Hemiptera (17 Coleoptera (36 Lepidoptera (5 Hymenoptera (14 species) Diptera (38 species). By na...

[This corrects the article on p. 26 in vol. 7, PMID: 26909039.].

Methanolic extract of 15 Iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (MCF7, HepG2, WEHI164) and one normal cell line (MDBK). Some plants showed cytotoxic activities. The extract of Ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. The major compounds of the most potent a...