نتایج جستجو برای: fg coating

تعداد نتایج: 41582  

2013
Laura Occhipinti Yiming Chang Martin Altvater Anna M. Menet Stefan Kemmler Vikram G. Panse

Multiple export receptors passage bound pre-ribosomes through nuclear pore complexes (NPCs) by transiently interacting with the Phe-Gly (FG) meshwork of their transport channels. Here, we reveal how the non-FG interacting yeast mRNA export factor Gly-Leu-FG lethal 2 (Gle2) functions in the export of the large pre-ribosomal subunit (pre-60S). Structure-guided studies uncovered conserved platform...

Journal: :Biological & pharmaceutical bulletin 2009
Yuko Ohta Jung-Bum Lee Kyoko Hayashi Toshimitsu Hayashi

A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1--> residue. In addition, pyruvic acid was suggested to be present as (1'-carbo...

2017
Yasukazu Yonetani Yoshio Matsui Yoshinari Tanaka Shuji Horibe

Background The posterior cruciate ligament (PCL) is a primary stabilizer of the knee in the posterior direction. However, PCL deficiency presents a clinical paradox because the outcome of PCL deficiency ranges from total disability to uninterrupted participation in competitive athletics. Purpose To investigate whether posterior laxity (PL) and the flexion gap (FG) influence the results of the...

2016
Takuya Maeyama Nobuhisa Fukunishi Kenichi L. Ishikawa Kazuaki Fukasaku Shigekazu Fukuda

The radiological properties of nanocomposite Fricke gel (NC-FG) dosimeters prepared with different concentrations of nano-clay, perchloric acid and ferrous ions in deaerated conditions were investigated under carbon and argon ion beam irradiation covering a linear-energy-transfer (LET) range of 10 to 3000 eV/nm. We found that NC-FG exhibits radiological properties distinct from those of convent...

2015
Loren E Hough Kaushik Dutta Samuel Sparks Deniz B Temel Alia Kamal Jaclyn Tetenbaum-Novatt Michael P Rout David Cowburn

Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules. Intrinsically disordered proteins (IDPs) containing phenylalanyl-glycyl (FG)-rich repeats line the pore and interact with TFs. However, the reason that transport can be both fast and spec...

2015
Rebecca L. Adams Laura J. Terry Susan R. Wente

FG nucleoporins (Nups) are the class of proteins that both generate the permeability barrier and mediate selective transport through the nuclear pore complex (NPC). The FG Nup family has 11 members in Saccharomyces cerevisiae, and the study of mutants lacking different FG domains has been instrumental in testing transport models. To continue analyzing the distinct functional roles of FG Nups in...

2017
Estelle Yau Carl Petersson Hugues Dolgos Sheila Annie Peters

Extensive gut metabolism is often associated with the risk of low and variable bioavailability. The prediction of the fraction of drug escaping gut wall metabolism as well as transporter-mediated secretion (Fg ) has been challenged by the lack of appropriate preclinical models. The purpose of this study is to compare the performance of models that are widely employed in the pharmaceutical indus...

2015
Gui-Ming Zhang Yao Zhu Hua-Lei Gan Hong-Kai Wang Guo-Hai Shi Hai-Liang Zhang Bo Dai Chao-Fu Wang Ding-Wei Ye Giandomenico Roviello.

Determination of Fuhrman grade (FG) on biopsies of renal masses is relatively inaccurate, being prone to underestimating the true grade as ascertained from surgical specimens. This study evaluated whether anatomical features of tumors could predict tumor upgrading between core biopsies and surgical specimens. We prospectively enrolled 249 patients undergoing surgical resection of solid renal ma...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
P N Tijburg M J Ijsseldijk J J Sixma P G de Groot

To study fibrin incorporation into thrombi at different wall shear rates, a new method to study fibrin deposition on extracellular matrixes underlying stimulated endothelial cells under flow conditions was developed. For this method, we used fibrinogen labeled with peroxidase (Fg-PO). Fg-PO was fully exchangeable for Fg in the clotting assays tested, and PO activity was bound to fibrin-specific...

Journal: :Molecular cancer research : MCR 2007
Teresita Reiner Alicia de Las Pozas Ricardo Parrondo Carlos Perez-Stable

Transgenic mice that allow targeting of SV40 T antigen (Tag) to the prostate provide a unique model to identify cancer-initiating cells and follow their progression from a normal cell phenotype into prostate cancer cells. We have developed the FG/Tag transgenic mouse model of prostate cancer using the human fetal globin (FG) promoter linked to Tag. Immunohistochemistry results show that before ...

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