Between 13 different serogroups of N. meningitidis, identified according to the capsular polysaccharide’s antigenic structure, only 5 (A, B, C, W-135 and Y) are clinically relevant and responsible for 90% cases of meningococcal invasive disease. In Italy, serogroup B is the principal cause of invasive meningococcal disease [1]. There are two types of tetravalent vaccines for serogroups A, C, W-...

KEY POINTS Concomitant administration of bivalent rLP2086 (Trumenba [Pfizer, Inc] and diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) was immunologically noninferior to DTaP/IPV and saline and was safe and well tolerated. Bivalent rLP2086 elicited robust and broad bactericidal antibody responses to diverse Neisseria meningitidis serogroup B strains exp...

The surfaces of many Gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated N-terminus; these proteins are referred to as surface lipoproteins or SLPs. In Neisseria meningitidis, SLPs such as transferrin-binding protein B (TbpB) and factor-H binding protein (fHbp) are essential for host colonization and infection because of their essential role...