Fibrinogen and factor XIII are two essential proteins that are involved directly in fibrin gel formation as the final step of a sequence of reactions triggered by a procoagulant stimulus. Haemostasis is the most obvious function of the resulting fibrin clot. Different variables affect the conversion of fibrinogen to fibrin as well as the mode of fibrin polymerisation and fibrin crosslinking, he...

Sections of human tumors have been stained for fibrin deposits by the fluorescein label technic. Large clots of extravascular fibrin were demonstrated in most of the tumors tested. No such large clots were found in the several normal tissues investi gated. However, there was some staining of certain areas of connective tissue in both normal and tumor tissues. The fibrin deposition observed in t...

An altered fibrin network architecture has been associated with premature coronary artery disease (CAD).1,2 Hypofibrinolysis, ie, impaired dissolution of fibrin in blood clots, is another common finding in such patients. Hypofibrinolysis is associated with elevated activity of inhibitors of the fibrinolytic process, particularly of plasminogen activator inhibitor-1 (PAI-1)3 and thrombin activat...

Steady-state kinetic parameters were determined for the action of human a-thrombin on human fibrin I polymer, an intermediate in the a-thrombin-catalyzed conversion of fibrinogen to the fibrin matrix of blood clots during the terminal phase of the blood clotting cascade. Values of 49 s-’ and 7.5 pM were determined (at 37 “C, pH 7.4, I’/2 0.17) for Lt and K,, respectively. Studies of the effect ...

The active ingredient of METALYSE (tenecteplase) is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modification at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher f...

BACKGROUND We sought to determine the efficacy of sutures, human fibrin glue and N-butyl-2-cyanoacrylate for mesh fixation in patients undergoing the plug and mesh procedure for groin hernia. METHODS A total of 156 patients with 167 inguinal hernias (11 bilateral) underwent a plug and mesh procedure and were randomly assigned to received either sutures (n = 59 hernias), human fibrin glue (n =...

EVALUATION OF FIBRIN HYDROGEL SCAFFOLD EFFECT ON OSTEOGENIC DIFFERENTIATION WHARTONS’S JELLY DERIVED MESENCHYMAL STEM CELLS