The present study determined the regenerative effect of bone marrow-derived stem cells (BMSCs) on thioacetamide (TA)-induced liver fibrosis in rats. A total of 30 male Wistar rats were randomly divided into sham control and treatment groups. The rats of the sham control group were subdivided into three groups and sampled on the 14th, 18th, and 20th weeks after fibrosis induction. The rats of th...

Epidermal changes including hyperkeratosis and epidermal verrucous changes, papillomatosis, secondary infection, recurrent erysipelas and ulceration are complications of chronic lymphedema. Elephantiasis is a term used for these significant changes. Xanthoma may also develop in lymphedematous areas. Lymphangiosarcoma is a rare complication of chronic lymphedema. Nodular fibrosis is mentioned as...

background: bone marrow-derived mesenchymal stem cells (bmmscs) transplantation has been considered as a promising milestone in liver fibrosis treatment. however, low amounts of homing are a major obstacle. we aimed to investigate the role of melatonin pretreatment in bmmsc homing into experimental liver fibrosis. methods: bmmscs were obtained, grown, propagated and preconditioned with 5 µm mel...

Peritoneal dialysis (PD) leads to structural and functional changes in the peritoneal membrane, endpoint of which is fibrosis. fibrosis diagnosed 50% 80% PD patients within 1 2 years treatment initiation, respectively. A key role development played by mesothelial-mesenchymal transformation, a complex biological process transition from mesothelium mesenchyme. This review summarizes current knowl...

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and accumulation fibrotic extracellular matrix (ECM). Currently, there a lack effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition phenotype associated with changes in chromatin structure, key determ...

Periostin (POSTN) is a type of matricellular protein, but its functions in adipose fibrosis remain unclear. Here, we found that POSTN expression significantly increased mouse tissue after treatment with lipopolysaccharide (LPS) or high‐fat diet (HFD) and progenitor cells are the main source POSTN. In our model fibrosis, deletion protected mice from probably through reducing accumulation macroph...

Chronic inflammation of the lungs is a major cause morbidity and mortality in patients with cystic fibrosis. One macrolides, azithromycin has antimicrobial, immunomodulatory, anti-inflammatory effects that are useful diseases chronic inflammatory processes such as This systematic review aimed to determine efficacy safety administration for fibrosis improving lung function. Pulmonary function wa...

Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority filtered water and glucose, as well all proteins through glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect tubule endocytosis processes, by disturbing overstressing endolysosoma...

Background: To establish and validate a radiomics-based model for staging liver fibrosis at contrast-enhanced CT images. Materials Methods: This retrospective study developed two models (R-score: radiomics signature; R-fibrosis: integrate radiomic serum variables) in training cohort of 332 patients (median age, 59 years; interquartile range, 51-67 256 men) with biopsy-proven who underwent b...