Transcription of the multiple antibiotic resistance marRAB operon increases when one of the sequence-related activators, MarA, SoxS, or Rob, binds to the "marbox" centered at -61.5 relative to the transcriptional start site. Previous deletion analyses showed that an adjacent upstream "accessory region" was needed to augment the marbox-dependent activation. To analyze the roles of the marbox and...

Efficient DNA inversion catalysed by the invertase Gin requires the cis-acting recombinational enhancer and the Escherichia coliFIS protein. Binding of FIS bends the enhancer DNA and, on a negatively supercoiled DNA inversion substrate, facilitates the formation of a synaptic complex with specific topology. Previous studies have indicated that FIS-independent Gin mutants can be isolated which h...

The Fis (factor for inversion stimulation) protein of Escherichia coli was found to influence the frequency of transposon Tn5 and insertion sequence IS50 transposition. Fis stimulated both Tn5 and IS50 transposition events and also inhibited IS50 transposition in Dam-bacteria. This influence was not due to regulation by Fis of the expression of the Tn5 transposition proteins. We localized, by D...

Fis is a key DNA-binding protein involved in nucleoid organization and modulation of many DNA transactions, including transcription in enteric bacteria. The regulon of genes whose expression is influenced by Fis in Salmonella enterica serovar Typhimurium (S. typhimurium) has been defined by DNA microarray analysis. These data suggest that Fis plays a central role in coordinating the expression ...

Transcription of the thrU(tufB) operon is trans-activated by the protein FIS which binds to the promoter upstream activator sequence (UAS). Deletions of parts of the UAS and insertions show that optimal trans-activation requires occupation by FIS of the two FIS-binding regions on the UAS and specific helical positioning of these regions. On the basis of these and other data, a model for the mec...

An emerging amount of data indicates a correlation between gender-related factors and regulation of virus infection and supports what is known in clinical circles, that these topics are of great importance in many infectious diseases. In the present study we found that young adult NMRI male mice are more susceptible to infection by a variant of Friend murine leukaemia virus, FIS-2, than are fem...

In this paper, we study an inherent problem of mining Frequent Itemsets (FIs): the number of FIs mined is often too large. The large number of FIs not only affects the mining performance, but also severely thwarts the application of FI mining. In the literature, Closed FIs (CFIs) and Maximal FIs (MFIs) are proposed as concise representations of FIs. However, the number of CFIs is still too larg...

Polycomb group (PcG) proteins are evolutionary conserved proteins that stably maintain established transcriptional patterns over cell generations. The FERTILIZATION INDEPENDENT SEED (FIS) PcG complex from plants has a similar composition to the Polycomb repressive complex 2 from animals. Mutations in FIS genes cause parent-of-origin-dependent seed abortion. Every seed inheriting a mutant fis al...

Feedback intervention (FI), that is, providing people with some information regarding their task performance, is one of the mostly widely applied psychological interventions. Yet there is a growing body of evidence that such interventions yield lughly variable effects on performance (Ilgen, Fisher, & Taylor, 1979; Kluger & DeNisi, 1996; Latham & Locke, 1991; Salmoni, Schmidt, & Walter, 1984). I...

An important and difficult issue in designing a Fuzzy Inference System (FIS) is the specification of fuzzy sets, and fuzzy rules. The aim of this paper is to demonstrate how an additional qualitative information, i.e., monotonicity property, can be exploited and extended to be part of an FIS designing procedure (i.e., fuzzy sets and fuzzy rules design). In this paper, the FIS is employed as an ...