Tumor cell-derived hyaluronidase HYAL-1 degrades hyaluronic acid (HA) into angiogenic fragments (AGF: 10-12 disaccharides). AGF support tumor growth and progression. Urine and tissue HAase/HYAL-1 levels are sensitive markers for high-grade bladder cancer (BCa) and its metastasis. In preclinical models of BCa, we evaluated whether o-sulfated AGF (sHA-F) inhibits HAase activity and has antitumor ...

To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubation times, diagnostic of a species barrier. PrP(Sc) of the new MH2M(Sc237) stra...

A total of 353 coagulase-negative staphylococcus (CNS) isolates from infected bovine mammary glands were tested for cytolysin production by using the synergistic hemolysin assay (SHA). Overall, 34.6% of CNS isolates were SHA positive. Human-associated, coagulase-negative staphylococcal species contained the greatest number of SHA-positive strains. Milk leukocyte levels expressed as somatic cell...

In this paper, we analyze the collision resistance of SHA-2 and provide the first results since the beginning of the NIST SHA-3 competition. We extend the previously best known semi-free-start collisions on SHA-256 from 24 to 32 (out of 64) steps and show a collision attack for 27 steps. All our attacks are practical and verified by colliding message pairs. We present the first automated tool f...

In this paper we describe the construction of Turbo SHA-2 family of cryptographic hash functions. They are built with design components from the SHA-2 family, but the new hash function has three times more chaining variables, it is more robust and resistant against generic multi-block collision attacks, its design is resistant against generic length extension attacks and it is 2 8 times faster ...

Hardware implementation quality is an important factor in selecting the NIST SHA-3 competition finalists. However, a comprehensive methodology to benchmark five final round SHA-3 candidates in ASIC is challenging. Many factors need to be considered, including application scenarios, target technologies and optimization goals. This work describes detailed steps in the silicon implementation of a ...

INTRODUCTION Serum hyaluronic acid (sHA) is a serum biomarker for knee osteoarthritis (OA). Although sHA concentration is elevated in patients with knee OA, the relationship between serum concentration and disease progression remains unclear. We examined the relationship between sHA concentration and radiographic progression of knee OA in a cohort of individuals followed for 5 years. METHODS ...

The weakening of the widely used SHA-1 hash function has also cast doubts on the strength of the related algorithms of the SHA-2 family. The US NIST has therefore initiated the SHA-3 competition in order to select a modern hash function algorithm as a “backup” for SHA-2. This algorithm should be efficiently implementable both in software and hardware under different constraints. In this paper, ...

In this article we find collisions for step-reduced SHA-256. We develop a differential that holds with high probability if the message satisfies certain conditions. We solve the equations that arise from the conditions. Due to the carefully chosen differential and word differences, the message expansion of SHA-256 has little effect on spreading the differences in the words. This helps us to fin...

In 2004, a new attack against SHA-1 has been proposed by a team leaded by Wang [15]. The aim of this article is to sophisticate and improve Wang’s attack by using algebraic techniques. We introduce new notions, namely semi-neutral bit and adjuster and propose then an improved message modification technique based on algebraic techniques. In the case of the 58-round SHA-1, the experimental comple...