Since the advent of the potent immunosuppressive agent FK 506, intestinal transplantation has become a feasible therapeutic option for patients with irreversible intestinal failure. In this chapter, we present our clinical experience with intestinal transplantation, focusing on the technical aspects of both the donor and recipient operations. The logistics of the operative procedure have been d...

H AMSTER-to-rat transplantation has been widely used to study xenotransplantation between the relatively closely related species. Recently, we developed the surgical procedure for kidney transplantation in this species combination. This study describes mechanisms of hamster kidney graft rejection in the rat and the effect of different treatment protocols, including FK 506, cyclophosphamide, and...

Abbreviations: ALT: Alanine Transaminase; AST: Aspartate Transaminase; BMI: Body Mass Index; CMV: Cytomegalovirus; Cnis: Calcineurin Inhibitors; Csa: Cyclosporine; FK Or FK-506: Tacrolimus; GRWR: Graft Recipient Weight Ratio; HAI: Histological Activity Index; HCC: Hepatocellular Carcinoma; HCV: Hepatitis C Virus; HCV RNA: Hepatitis C Virus Ribonuclic Acid; HPB: Hepatopancreatobiliary;LDLT: Livi...

Ten dogs that survived the perioperative events of liver transplantation were treated with 1 mg/kg/d oral FK. Eight of the recipients lived for at least 1 month postoperatively, and seven are still alive with normal hepatic function after 35 to 65 days. The consistency and good quality of results with this difficult transplant preparation using FK, in spite of its rumored great toxicity in dogs...

T HE PROCESS of cellular uptake and metabolism of cyclosporine (CsA) is poorly understood. Previously, we have shown that the transport of CsA in blood occurs in association with plasma Iipoproteins,l with low-density lipoprotein (LOL), and with highdensity lipoprotein, each transporting about 32% of the total amount of CsA in blood. This observation raises the possibility that further cellular...

FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O. The compound suppressed immune responses in vitro and in vivo with mice. This immunosuppressive effect was more potent than that of ciclosporin.

FK506 (Tacrolimus) is a potent inhibitor of calcineurin that blocks IL2 production and is widely used to prevent transplant rejection and treat autoimmunity. FK506 treatment of dendritic cells (FKDC) limits their capacity to stimulate T cell responses. FK506 does not prevent DC survival, maturation, or costimulatory molecule expression, suggesting that the limited capacity of FKDC to stimulate ...

THE anticomplement agent K-76 COOH (K76). which mainly inhibits C5 activation. has been effectively used to mitigate experimental immune complex glomerulonephritis and ulcerative colitis.1.2 The effectiveness of K76. alone or in combination with FK 506 and cyclophosphamide (CP). in preventing xenograft rejection was studied using the hamster-to-rat and guinea pig-to-rat heart transplantation mo...