C YCLOSPORINE (CyA) has been a major advance in the armamentarium of immunosuppressive agents used in clinical transplantation. The use of Cy A and steroids has increased patient and graft survival in human transplantation. 1 ,2 Rejection continues to be the most common cause of retransplantation, and death is often a sequela of treatment of rejection. A number of adverse effects of CyA have be...

The immunosuppressant FK506 binds Plasmodium falciparum FK-506 binding protein 35 (PfFKBP35) and shows anti-malarial activity. To understand molecular mechanism of the drug on the parasite, we have done NMR studies. Here, we report the assignment of FK506-binding domain of PfFKBP35.

By retrospective analysis of 13,000 blood samples obtained from 248 patients receiving FK 506 therapy, we compared the suitability of plasma with that of whole blood as the matrix for therapeutic drug monitoring of FK 506. The plasma concentrations did not correlate with the concentrations in whole blood (r = 0.56). In contrast to plasma samples (analyzed by enzyme immunoassay), FK 506 was dete...

Abstnct: Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the punne biosynthesis inhibitors mycophcnolic acid (MPA; the active mOlctv of RS6l443) and mizoribine (MZB) when used alone or in combination. When added at the initiation of six·day human mixed lymphocyte cultures (MLC). FK 506. MPA or MZB exhibited dose·d...

We have taken the opportunity of a clinical trial of the potential efficacy and safety of FK 506 (tacrolimus) in chronic progressive multiple sclerosis (MS) to examine the influence of this potent new immunosuppressant on circulating T-lymphocytes in an otherwise healthy non-transplant population. Peripheral blood levels of subsets of CD4+ T lymphocytes expressing the activation molecule interl...

Article type: Original article Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus), a phosphatase inhibitor, is a fungalderived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages of learning and memory ...

TRANSPLANTED pancreatic islet tissue has been shown to restore normoglycemia and prevent the development of chronic complications in diabetic animals. 1 The application of alloand xenotransplantation of pancreatic islets for the treatment of diabetes is hindered by immune rejection. FK 506, a new immunosuppressive agent, has been demonstrated to be effective in the prolongation of survival of h...

The effect of a 14-day administration of FK-506 at 1 or 3 mgflcg ofi plasma lipids and myocardial energy and glucose metabolism in rats was investigated. FK-506 increased the level of blood glucose in rats when given daily at an oral dosage of 3 mgrkg for 14 days. T?ie plasma ]evel of total cholesterol was significantly increased by F}(-506 at either 1 or 3 mgXkg, whereas that of triglyceride w...