A sensitive, specific, reproducible and optimized high performance liquid chromatography with fluorescence detection (HPLC-FLD) method for the determination of bergapten in rat plasma was established and applied to the pharmacokinetic and bioavailability study in rat after oral and intravenous administration of bergapten. The method was also successfully applied to the excretion study of bergap...

BACKGROUND Ferredoxin-NADP(H) reductase (FNR) from Pisum sativum and Flavodoxin (Fld) from Anabaena PCC 7119 have been reported to protect a variety of cells and organisms from oxidative insults. In this work, these two proteins were expressed in mitochondria of Cos-7 cells and tested for their efficacy to protect these cells from oxidative stress in vitro. PRINCIPAL FINDINGS Cos-7/pFNR and C...

BACKGROUND The association between diet and fatty liver disease (FLD) has predominantly been analyzed for single nutrients or foods, and findings have been inconsistent. OBJECTIVE We aimed to compare associations of hypothesis-driven and exploratory dietary pattern scores with liver fat content. DESIGN Liver fat was measured by using magnetic resonance imaging as liver signal intensity (LSI...

PURPOSE To determine high resolution computed tomography (HRCT) patterns and pulmonary function indices which are associated with increased mortality in patients with connective tissue disease related fibrotic lung disease (CTD-FLD). METHODS HRCTs from 168 patients with CTD-FLD were scored by 2 observers for a variety of HRCT patterns and traction bronchiectasis. A radiological diagnosis of u...

The primary function of Photosystem I (PSI)1 during photosynthesis is to provide reducing equivalents, in the form of NADPH, that will then be used in CO2 assimilation (Golbeck, 2006). In plants, this occurs via reduction of the soluble [2Fe-2S] Ferredoxin (Fd) by PSI. Subsequent reduction of NADP+ by Fdrd is catalysed by the FAD-dependent FerredoxinNADP+ reductase (FNR) (Eox/hq = -374 mV at pH...

When analyzing database query languages a property of theories, the pseudo-finite homogeneity property has been introduced and applied (cf. [3]). We show that a stable theory has the pseudo-finite homogeneity property just in case its expressive power for finite states is bounded. Moreover, we introduce the corresponding pseudo-finite saturation property and show that a theory fails to have the...

This paper proposes a new method of face image feature extraction, namely, the fuzzy 2DFLD (F2DFLD) based on the 2D fisher discriminant criterion and fuzzy set theory. In the proposed method, we calculate membership degree matrix by FKNN, then we incorporate the membership degree into the definition of the between-class scatter matrix and within-class scatter matrix and get the fuzzy between-cl...

Flavanols are a class of polyphenols that have become the focus much research because their medicinal properties. For this paper, new method to determine in nutraceutical samples was developed, based on solid-liquid extraction and further analysis by liquid chromatography. Analytes were recovered ultrasound-assisted extraction, using mixture methanol/water/hydrochloric acid (70:29:1, v:v:v) as ...

Fatty Liver Disease (FLD) is an increasing prevalent disease that can be reversed if detected early. Ultrasound is the safest and ubiquitous method for identifying FLD. Since expert sonographers are required to accurately interpret the liver ultrasound images, lack of the same will result in inter-observer variability. For more objective interpretation, high accuracy, and quick second opinions,...

The enormous power of modern computers has made possible the statistical modelling of data with dimensionality that would have made this task inconceivable only decades ago. However, experience in such modelling has made researchers aware of many issues associated with working in high-dimensional domains, collectively known as ‘the curse of dimensionality’, which can confound practitioners’ des...