OBJECTIVE Acorus calamus (A. calamus) has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of A. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS). MATERIALS AND METHODS The via...

Abstract OBJECTIVE Translocator protein (TSPO) PET imaging is used in different neurological diseases and emerges as new tool for the diagnosis therapy planning of glioma patients. Various signal sources TSPO-PET signal, however, hamper image interpretation biological understanding. Here we assess TSPO expression ligand uptake a murine model human tissue derived from METHODS Mice with implanted...

Myeloid sarcoma is a tumor mass consisting of myeloid blasts, with or without maturation, occurring in an anatomical site other than bone marrow. More 2000 case reports so far, only few comprehensive studies have been done, which reflects the rarity and difficulties treatment this neoplasm. : A 17-year-old female presented complaints neck swelling since 2 months, breathlessness 5 days. PET CT- ...

Abstract Background and Aims Systemic Lupus Erythematosus (SLE) is characterized by a shift to senescent B cells, namely, switched memory (SM) (CD19+IgD-CD27+) exhausted-double negative (DN) (CD19+IgD-CD27-) subtypes. The aim of this study was evaluate the impact T cell immunity in distinct - pattern SLE. Method A wide range exhaustion related lymphocyte surface molecules, including CD45RA, CCR...

BACKGROUND AND OBJECTIVES The rapidly increasing number of diabetic patients across the world drew the attention to develop more effective therapeutic approaches. Recent investigations on newly differentiated insulin producing cells (IPCs) revealed that they could be derived from embryonic, adult mesenchymal and hematopoietic stem cells. This work was planned to evaluate the role of StemEnhance...

BACKGROUND Hyper IgE syndrome (HIES) is a rare primary immunodeficiency disorder characterized by the triad of elevated IgE and eosinophilia, eczema and recurrent skin and pulmonary infections. Mutation in the STAT3 gene accounts for majority of the autosomal dominant and sporadic forms of HIES. OBJECTIVE To report clinical and molecular analyses of patients with Hyper IgE syndrome from a sin...

BACKGROUND The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune compromised. OBJECTIVE To chart the baseline levels of T-cell subpopulation frequencies in patients with cancer prior to treatment. SUBJECTS AND METHODS Blood samples of patients were taken at the time of diagnosis, analysed with flowcytometry a...

RhoB, a member of small GTPases belonging to the Ras protein superfamily, might have a suppressive activity in cancer progression. Here, expression of RhoB gene was evaluated in human benign, borderline and malignant ovary tumors by immunostaining, with normal ovary tissue as control. Malignant tumors were assessed according to Federation Internationale de Gynecologie Obstetrique (FIGO) guideli...