It has been known for many years that an excess of thrombin is formed during the clotting of blood or plasma, that the excess is rapidly inactivated, and that such inactivation is important in maintaining normal fluidity of the blood (1). Considerable attention has been given to the question of what happens to the excess of thrombin, but little conclusive information has been obtained concernin...

In this paper we examine the effect of mild stenosis on blood flow, in an irregular axisymmetric artery with oscillating pressure gradient. The Herschel-Bulkley fluid model has been utilized for this study. The combined influence of an asymmetric shape and surface irregularities of constriction has been explored in this computational study. An extensive quantitative analysis has been performed ...

Fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene was used to study the lymphocyte membrane in rheumatoid arthritis. The increase of polarisation value in the patients (n = 27) compared with healthy controls (n = 32) suggests a decrease of membrane fluidity. Moreover, erythrocyte sedimentation rate (ESR) and plasma fibrinogen concentrations were positively correlated with lymphocyte fl...

The solubility of the spin label TEMPO (I) in membranes depends on the fluidity of the membrane. An empir ical relat ionship has been establ ished between TEMPO solubility and fluidity, measured by the order parameter S~o. This relationship is employed to determine the fract ion of the lipid in membranes of rabbit muscle sarcoplasmic re t iculum that is in a fluid state. We find that 84% of the...

During the course of this project dCSE Fluidity-ICOM has been transformed from a code that was primarily used on institution level clusters with typically 64 tasks used per simulation into a highly performing scalable code which can be run efficiently on 4096 cores of the current HECToR hardware (Cray XT4 Phase2a). Fluidity-ICOM has been parallelised with MPI and optimised for HECToR alongside ...

The influence of lindane (gamma-hexachlorocyclohexane) on fluidity of plasma membranes from rat renal cortical tubules has been investigated. Preincubation with lindane increased membrane fluidity. This effect was accompanied by (i) a decrease in the transport of glucose with regard to the controls and (ii) an inhibition of the beta-adrenergic stimulatory activity upon cyclic AMP accumulation. ...