Flutamide is a non-steroidal anti-androgenic drug, commonly used in the treatment of advanced prostate cancer, acne and hirsutism. This drug may induce various degrees of liver injury, including acute liver failure (ALF), with further need for liver transplantation. Here, we present a report of 10 consecutive patients seen in a period of 14 years, with acute liver toxicity induced by flutamide ...

Prostate cancer is the most common noncutaneous malignancy of American men. Although it can be initially treated with androgen deprivation therapy, tumors that relapse become resistant to future hormonal manipulation. We previously found that the multidrug resistance protein (MRP), MRP1, is overexpressed in advanced stage and grade human prostate cancer and is negatively regulated by p53. In th...

The present work was aimed at formulating a SMEDDS (Self-microemulsifying drug delivery system) for oral drug delivery system containing flutamide. The solubility of flutamide was determined in various vehicles. Pseudo ternary phase diagram was constructed to identify the micro emulsification existence area. SMEDDS formulations were tested for microemulsifying properties, and the resultant form...

OBJECTIVES The objective of this study was to evaluate efficacy, safety, and dose-response profiles of four dosing schemes of flutamide over 24 weeks. METHODS Patients were randomized to receive one of the following five treatment regimens for a period of 24 weeks: placebo capsule, flutamide capsules 125 mg twice daily, 250 mg once daily, 250 mg twice daily, and 250 mg three times daily. Pati...

The prevalence of major depressive disorder (MDD) in adult men is roughly half that of women. Clinical evidence supports a protective effect of androgens against depressive disorders in men. The developing brain is subject to androgen exposure but a potential role for this in depression during adulthood has not been considered. In order to explore this question we treated newborn male rat pups ...

INTRODUCTION We have recently demonstrated that antiandrogen treatment during fetal life resulted in delayed folliculogenesis. The aim of the present study was to investigate the effect of androgen deficiency induced by flutamide on the expression of TGFβ superfamily members and their receptors which are involved in follicle formation and its transition to the primary stage. MATERIAL AND METH...

Sexually dimorphic behavior in nonhuman primates results from behavioral predispositions organized by prenatal androgens. The rhesus monkey has been the primary primate model for understanding the hormonal organization of sexually dimorphic behavior. Historically, female fetuses have received high prenatal androgen doses to investigate the masculinizing and defeminizing effects of androgens. Su...

OBJECTIVES To assess whether flutamide (Drogenil), a pure androgen receptor blocking agent, improves survival in patients with pancreatic carcinoma and thus whether testosterone is a major growth factor for this tumour. DESIGN A prospective, randomised, double blind placebo controlled trial. SUBJECTS 49 patients with a clinical diagnosis of pancreatic carcinoma. INTERVENTIONS 24 patients ...

Present study was designed to establish a causal connection between changes in the cell-cell junction protein expression at the blood-testis barrier (BTB) and alterations in the adult rat testis histology following an anti-androgen flutamide exposure. Particular emphasis was placed on the basal ectoplasmic specialization (bES) in the seminiferous epithelium and expression of gap and tight junct...

Objective: To compare finasteride plus flutamide versus flutamide alone in men with biochemically recurrent prostate cancer. Design/Methods: This was a non-randomized phase II study which enrolled 56 men with biochemically recurrent prostate cancer. Men were sequentially assigned to their treatment arm. The first 36 were treated with combination low-dose flutamide plus finasteride while the sub...