Investigations at Pirbright have shown that strains of virus which a re attenuated and immunogenic for cattle were also attenuated for sheep and produced a good immune response (Report, 1964). The work of Geering & Pay (1963) included studies with the RV11 vaccine strain, which at a high dosage level caused no post vaccinal reactions in a group of twenty four-month old lambs. Examination of the...

Fading immune protection in farmed animals may present a problem, particularly in free-ranging animals in nomadic and transhumant pastoral systems, where animals are not readily available for large-scale blanket vaccination programmes. Two veterinary examples of fading immune protection are discussed: rinderpest and foot-and-mouth disease (FMD). Both are devastating viral diseases of cattle tha...

Background and Aims: Foot-and-Mouth Disease (FMD) is a highly contagious infectious disease of livestock which has made a barrier to hygiene causing severe loss in livestock and their products. The aim of this study was the assessment of antibody response against foot and mouth disease virus  types A13, A15 , O2010, after injection of FMD vaccine candidate produced by Razi Institue. Mater...

Foot and mouth disease (FMD) affects cloven-footed animals. It is caused by seven species ("types") of Foot and Mouth virus (FMDV) in the genus aphthovirus, family Picornaviridae (). FMDV is a single-stranded RNA virus, with a protein coat consisting of four capsid proteins enumerated as VP1, VP2, VP3, and VP4 (Garland and Donaldson 1990).

BACKGROUND Clinically, sheeppox and goatpox have the same symptoms and cannot be distinguished serologically. A cheaper and easy method for differential diagnosis is important in control of this disease in endemic region. METHODS A duplex PCR assay was developed for the specific differential detection of Goatpox virus (GTPV) and Sheeppox virus (SPPV), using two sets of primers based on viral ...

Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants. Quasispecies dynamics predicts, and clinical results have confirmed, that combination therapy has an advantage over monotherapy to delay or prevent selection of inhi...

Reconstructing the evolutionary history, demographic signal and dispersal processes from viral genome sequences contributes to our understanding of the epidemiological dynamics underlying epizootic events. In this study, a Bayesian phylogenetic framework was used to explore the phylodynamics and spatio-temporal dispersion of the O CATHAY topotype of foot-and-mouth disease virus (FMDV) that caus...