This study investigated the effect of maternal pinealectomy and postnatal pinealectomy on affective responses. Siberian hamsters were born to either pinealectomized or sham-operated dams and then underwent pinealectomy or a sham operation. Maternal pinealectomy increased depressive-like responses of offspring in the forced swim test. Maternal pinealectomy increased rearing behaviour and postnat...

Objective: A question raised here as to whether exercise training combined with Mg supplementation could improve the symptoms of neuropathic pain such as the thermal hyperalgesia more effectively than either of the two alone. This study aimed to investigate the combined effect of swim training and Mg supplementation on thermal hyperalgesia in streptozotocin (STZ) induced diabetic rats. Materia...

Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 channels are involved in psychiatric disorders remains unexplored. Here, we tested the antidepressan...

The stress response is a multifaceted physiological reaction that engages a wide range of systems. Animal studies examining stress and the stress response employ diverse methods as stressors. While many of these stressors are capable of inducing a stress response in animals, a need exists for an ethologically relevant stressor for female rats. The purpose of the current study was to use an etho...

The effect of Eleutherococcus senticosus , Rhaponticum carthamoides and Schisandra chinensis extracts in doses 10, 25, 50 75 mg/kg were studied. actoprotective activity the studied adaptogens was assessed on outbred female mice a forced swim test with load 10% animal's body weight. Dry (50 mg/kg), (10 mg/kg) (25 found to exhibit most pronounced activity.