Structures and connections in the medial temporal lobe of humans and nonhuman primates have long been recognized as important for normal memory and emotional behavior. The present study investigated memory and emotional behavior in normal monkeys and six groups of monkeys with lesions of the medial temporal lobe. Two groups had damage to the hippocampal formation (or adjacent perirhinal and par...

DNA replication is sensitive to damage in the template. To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways. Crucial for error-free DNA damage tolerance is template switching, which depends on the formation and resolution of damage-bypass intermediates consisting of sister c...

In this work, scaling tendency and amount of precipitation of barium sulfate (BaSO4) were determined; the process is depending on temperature, pressure and mixing ratio of injection and formation of waters. Results showed that BaSO4 precipitation is largely dependent on mixing ratio. Temperature and pressure had no influence on BaSO4 precipitation. Different sca...

Precisely describing the formation and evolution rules of coal-rock fracturing crack have great value on reservoir fracturing improvement and highly efficient mining of coal bed methane well. In this paper, a non-linear dynamic method is used to study crack damage evolution behavior of coal-rock fracturing. Considering distribution characteristics of natural cracks in coal-rock, and based on da...

Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen metabolites. O-Acetylation of the N-hydroxy form of an arylamine yields an acetoxyarylamine, which can form a highly reactive arylnitrenium ion, the ultimate metabolite responsible for DNA adduct formation. However, we demonstrate here that the N-hydroxy and nitroso forms of arylamines can also in...

by Travis L. Turnbull Human cortical bone, like many engineering materials, is subject to damage and fracture, especially resulting from cyclic loading conditions routinely experienced by the load-bearing long bones. Unlike other materials, bone possesses a unique ability to repair damage and prevent or reduce fracture risk. However, in cases such as athletes and military recruits, the rate and...

Water injection is an enhanced oil recovery method which is applied for number of reservoirs especially in the offshore fields around the world. Sea-water injection process is usually associated with important concerns affecting the efficiency, safety, and economy of the operation like formation damage, mineral scaling, early breakthrough and corrosion. Incompatibility between injected and ...

BACKGROUND A shared feature among cardiovascular disease risk factors is increased oxidative stress. Because mitochondria are susceptible to damage mediated by oxidative stress, we hypothesized that risk factors (secondhand smoke and hypercholesterolemia) are associated with increased mitochondrial damage in cardiovascular tissues. METHODS AND RESULTS Atherosclerotic lesion formation, mitocho...

DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) are under investigation for the treatment of cancer, including the plasma cell malignancy multiple myeloma (MM). Evidence exists that DNA damage and repair contribute to the cytotoxicity mediated by the DNMTi decitabine. Here, we investigated the DNA damage response (DDR) induced by decitabine in MM using 4 huma...