We investigate the free-edge stresses in anisotropic bimaterials through the use of the free-edge stress intensity factor, Kf . This requires a determination of the singularity order at the free-surface as well as a calculation of the near-field stresses. We determine the order of the singularity for arbitrary free-surface orientation of the upper material using an eigenvalue analysis for aniso...

Routine therapeutic drug monitoring (TDM) reports only total vancomycin (VAN) concentrations, although protein binding varies and it is generally accepted that only free VAN is active. The aims of this study were to examine the correlation between free and total VAN concentrations in order to estimate whether free VAN levels can be predicted based on its total concentration. A high-performance ...

the seasonal and diurnal variations in the incidence of hypertension, cerebrovascular accident, coronary heart disease were well documented, but the relation between season and daytime on the onset of aneurysmal subarachnoid hemorrhage (asah) was a subject of controversy. in the present study we aimed to evaluate the role of season of year and diurnal changes on the onset of asah. the time was ...

Although evidence that survival decreases with age in animal species is compelling, the existence of variation in aging rates across different populations of a given species is still questioned. Here, we compared aging rates of 22 pairs of ruminant species living in captive and free-ranging conditions. Based on the recent suggestion that feeding niche is a key factor influencing aging in captiv...

background: obesity seems to be associated to migraine headache. increase in body fat, especially in gluteofemoral region, elevates adiponectin and leptin secretion which in turn impair inflammatory processes that could be contributing to migraine risk. this study was designed to assess the relationship between body composition and risk of migraine for the first time. methods: in this cross-sec...

chlorite flakes, as a product of alteration of biotite, the dominant ferromagnesian mineral in the paleozoic granitic rocks of the canadian appalachians, have been analyzed by electron microprobe for major elements and by 57fe m?ssbauer spectroscopy for the coordination and oxidation state of fe. comparison of m?ssbauer fe3+/fe ratios obtained from chlorite and its host biotite indicates that c...

understanding genetic structure and status of genetic variation of fasciola hepatica isolates from different hosts, has important implications on epidemiology and effective control of fasciolosis. random amplified polymorphic dna (rapd-pcr) was used to study the genetic variation of f. hepatica in sheep and cattle. dna was extracted from adult helminthes removed from livers of each infected ani...

BACKGROUND A new immunoassay for free light chain measurements has been reported to be useful for the diagnosis and monitoring of monoclonal light chain diseases and nonsecretory myeloma. We describe experience with and some potential pitfalls of the assay. METHODS The assay was assessed for precision, sample type and stability, recovery, and harmonization of results between two analyzers on ...