OBJECTIVE We evaluated a battery of Glucose-6-Phosphate Dehydrogenase diagnostic point-of-care tests (PoC) to assess the most suitable product in terms of performance and operational characteristics for remote areas. METHODS Samples were collected in Puerto Princesa City, Palawan, Philippines and tested for G6PD deficiency with a fluorescent spot test (FST; Procedure 203, Trinity Biotech, Ire...

We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test (FST), an assay used to study depression. Because CREB regulates expression of dynorphin (which acts at kappa-opioid receptors) in NAc neurons, these findings raised the possibility that kappa-receptors mediate immobility behaviors in the...

Three to four hundred new or renovated turfgrass systems are constructed in the U.S. each year. Many of these systems (golf courses, city parks, and residential and institutional lawns) are constructed in agricultural and silvicultural environments. However, knowledge of the water quality impact in transitioning from an agricultural or silvicultural landscape to a turfgrass landscape is at best...

Pro-inflammatory cytokines and other molecules traditionally associated with immune function have been implicated in mediating behavioral and physiological consequences of stressor exposure. There is also evidence that cytokines are aberrantly expressed in depressive populations, suggesting they may play an etiological role in the development of depression/despair-related processes. Thus, we co...

Although Interferon-alpha (IFN-α) is a powerful drug in treating several viral infections and certain tumors, a considerable amount of neuropsychiatry side-effects such as depression and anxiety are unavoidable consequence. Combination with selective serotonin (5-HT) reuptake inhibitor (SSRI) fluoxetine significantly improved the situation. However, the potential 5-HT1A receptorand 5-HT1B recep...

PURPOSE We examined associations among myostatin (MSTN) 2379 A > G and 163 G > A and follistatin (FST) -5003 A > T and -833 G > T single nucleotide polymorphisms (SNP) on the muscle size and the strength response to resistance training (RT). METHODS Subjects (n = 645, age = 24.1 +/- 0.2 yr, body mass index [BMI] = 24.2 +/- 0.2 kg x m(-2)) self-disclosed themselves as Caucasian (78.9%), Africa...

Exposure of exponentially growing human promyelocytic of lymphocytic leukemic cells to the putative DNA topoisomerase II inhibitor fostriecin (FST), at a concentration of 1 microM, results in the suppression of their rate of progression through the S and G2 phases of the cell cycle. At concentrations between 5 microM and 0.5 mM, FST triggers endonucleolytic DNA degradation in human promyelocyti...

Objective: Corticosterone treatment in mice impairs mitochondrial function, decreases energy production the brain, and induces depressive-like behaviors. Creatine (Crt) is vital for homeostasis brain. Alpha-lipoic acid (ALA) improves function reduces oxidative stress. The aim was investigating effect of Crt ALA following dexamethasone (Dexa) induced depression model despair. Methods: Female (22...

Perguruan tinggi di Indonesia diwajibkan untuk meggalakkan riset. Karya ilmiah merupakan salah satu bentuk riset menentukan peringkat suatu universitas. Penelitian ini bertujuan mengobservasi apakh dampak pandemi covid-19 berpengaruh pada jumlah publikasi karya eksak dan ilmu sosial. Studi menggunakan metode kuantitatif berbasis survey. Data yang digunakan data sekunder diambil dari website rep...

CONTEXT Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurv...