Atrial natriuretic peptide (ANP) is an important regulator of blood pressure (BP). One of the mechanisms whereby ANP impacts BP is by stimulation of nitric oxide (NO) production in different tissues involved in BP control. We hypothesized that ANP-stimulated NO is impaired in the kidneys of spontaneously hypertensive rats (SHR) and this contributes to the development and/or maintenance of high ...

Atrial natriuretic peptides (ANP) have recently been identified in both heart and CNS. These peptides possess potent natriuretic, diuretic, and vasorelaxant activities, and are all apparently derived from a single prohormone. Specific ANP binding sites have been characterized in the adrenal zona glomerulosa and kidney cortex, and one study reported ANP binding sites in the CNS. However, a detai...

With the increasing demand for clean and low-carbon energy, high proportion of renewable energy has been integrated into receiving-end grid. The grid-side storage project can ensure safe stable operation grid, but it still faces many problems, such as initial investment, difficult maintenance, unclear profit model, lack business mode. Therefore, is great significance to evaluate comprehensive b...

Hydrogen is an environmentally friendly source of renewable energy. Energy generation from hydrogen has not yet been widely commercialized due to issues related risk management in its storage and transportation. In this paper, the authors propose a hybrid multiple-criteria decision-making (MCDM)-based method manage risks involved transportation (RSTH). First, we identified key points RSTH by ex...

Iran is one of the flood-prone areas in world with inappropriate climatic patterns. In this study, flood risk maps three scenarios by combining Analytic Hierarchy Process (AHP), Analytical Network (ANP) and Fuzzy (FAHP) models Ordered Weighted Average (OWA), Linear Combination (WLC) models., Local (LWLC) two new models, Multi-Criteria Analysis (WMCA) Geo Technique for Order Preference Similarit...

The aim of the current study was to present the spatial distribution of atrial natriuretic peptide (ANP) in short-term cultures of pig granulosa cells obtained from small, medium, and large ovarian follicles. The specific immunoreactivity was detected by three monoclonal antibodies recognizing different epitopes of the ANP molecule (Mab 6C3, Mab 6F11, Mab5D3). The specific ANP immunoreactivity ...

BACKGROUND The hormone atrial natriuretic peptide (ANP) causes bronchodilation and partially protects against direct and indirect bronchial challenges. Both in vitro and in vivo studies have found that the protective effect of ANP against bronchoconstriction is enhanced by inhibition of the enzyme neutral endopeptidase (NEP). It was hypothesised that pretreatment with thiorphan, an NEP inhibito...

M-atrial natriuretic peptide (ANP; M-ANP) is a novel next generation 40 amino acid peptide based on ANP, which is highly resistant to enzymatic degradation and has greater and more sustained beneficial actions compared with ANP. The current study was designed to advance our understanding of the therapeutic potential of M-ANP in a canine model of acute angiotensin II–induced hypertension with el...

M-atrial natriuretic peptide (ANP; M-ANP) is a novel next generation 40 amino acid peptide based on ANP, which is highly resistant to enzymatic degradation and has greater and more sustained beneficial actions compared with ANP. The current study was designed to advance our understanding of the therapeutic potential of M-ANP in a canine model of acute angiotensin II-induced hypertension with el...