The dense granule of Toxoplasma gondii is a secretory vesicular organelle of which the proteins participate in the modification of the parasitophorous vacuole (PV) and PV membrane for the maintenance of intracellular parasitism in almost all nucleated host cells. In this review, the archives on the research of GRA proteins are reviewed on the foci of finding GRA proteins, characterizing molecul...

Inflammatory responses in many cell types are coordinately regulated by the opposing actions of NF-kB and the glucocorticoid receptor (GR). The human glucocorticoid receptor (hGR) gene encodes two protein isoforms: a cytoplasmic alpha form (GRa), which binds hormone, translocates to the nucleus, and regulates gene transcription, and a nuclear localized beta isoform (GRb), which does not bind kn...

The main serological marker for the diagnosis of recent toxoplasmosis is the specific IgM antibody, along with IgG antibodies of low avidity. However, in some patients these antibodies may persist long after the acute/recent phase, contributing to misdiagnosis in suspected cases of toxoplasmosis. In the present study, the diagnostic efficiency of ELISA was evaluated, with the use of peptides de...

The research scope of grey relational analysis has not been developed in recent years, and the exiting GRA models are all based on three perspectives, including distance perspective, slope perspective, and area perspective. Under this situation, a novel model called grey relational analysis based on angle perspective (GRAAP) was developed in this paper for the first time, and this model can exp...

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

Aiming at the risk assessment requirements of typical industrial control systems with integrated architecture security and safety, we propose an objective quantitative safety scheme based on Fuzzy Analytic Hierarchy Process (FAHP). First, establish a (SSI) for measures into failure modes. On this basis, hierarchical model SSI mode as element evaluation layer, then standardize characteristic val...

Energy resources are classified as renewable and non-renewable in general. Non renewable energy resources have been exhausted gradually. Renewable energy resources such as wind power, hydropower, geothermal power, solar power and photovoltaic power have importance more than ever before. But, researchers are looking for selections of renewable electricity generation as it is a technological prob...

The aim of this paper to review the Taguchi based Grey relational analysis is used to find the best process parameters and improved quality results. The GRA was proposed to optimize the multi response problem by making use of the grey relational coefficient and grey relational grade. GRA is attempted to integrate multiple responses, it is feasible to combine GRA with Taguchi method to provide a...

Glucocorticoid remediable aldosteronism (GRA), an autosomal dominant cause of primary aldosteronism, has been described as resulting in severe hypertension with premature death from stroke. We describe two new large pedigrees which include subjects who have the abnormal chimaeric gene strongly linked to GRA. The majority of affected members, who have only mild hypertension and normal biochemist...