Cytolytic granule-mediated target cell killing is effected in part through synergistic action of the membrane-acting protein perforin and serine proteases such as granzymes A (GrA) or B (GrB). In the present study we examine GrA cellular entry and nuclear uptake in intact mouse myeloid FDC-P1 cells exposed to perforin using confocal laser scanning microscopy, as well as reconstitute GrA nuclear...

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

The growth of healthcare waste (HCW) was driven by the spread COVID-19. Effective HCW eradication has become a pressing global issue that requires immediate attention. Selecting an effective treatment technology (HCWTT) can aid in preventing buildup. HCWTT selection be seen as complex multi-criteria group evaluation problem process involves multiple types criteria and decision-makers (DMs) faci...

Global economic competition has spurred the manufacturing sector to improve and invest in modern equipment to satisfy the needs of the market. In particular, machine tool selection is the most important problem; it plays a primary role in the improvement of productivity and flexibility in the manufacturing environment and involves the imprecise, vague and uncertain information. This paper prese...

Software Estimations provide an inclusive set of directives for software project developers, project managers, and the management in order to produce more realistic estimates based on deficient, uncertain, and noisy data. A range of estimation models are being explored in the industry, as well as in academia, for research purposes but choosing the best model is quite intricate. Estimation by An...

Staphylococcus aureus is a major pathogen in humans and causes serious problems due to antibiotic resistance. We investigated the antimicrobial effect of glycyrrhetinic acid (GRA) and its derivatives against 50 clinical S. aureus strains, including 18 methicillin-resistant strains. The minimum inhibitory concentrations (MICs) of GRA, dipotassium glycyrrhizate, disodium succinoyl glycyrrhetinate...

We have previously evaluated the beneficial effect of the group reminiscence approach (GRA) in patients with vascular dementia (VaD) in respect of cognitive and observed behavioral parameters [1] . Sixty patients who had been diagnosed with VaD were randomly assigned to three arms: a GRA arm, a social contact (SC) arm, and a control arm. A 1-hour session of GRA and SC was held once a week for 3...