The 40–42 residue amyloid -protein (A ) plays a central role in the pathogenesis of Alzheimer’s disease (AD). Of the two main alloforms, A 40 and A 42, the longer A 42 is linked particularly strongly to AD. Despite the relatively small two amino acid length difference in primary structure, in vitro studies demonstrate that A 40 and A 42 oligomerize through distinct pathways. Recently, a discret...

The mechanosensitive channel of large conductance, MscL, has been proposed as a triggered nanovalve to be used in drug release and other nanodevices. It is a small homopentameric bacterial protein that has the largest gated pore known: greater than 30 Å. Large molecules, even small proteins can be released through MscL. Although MscL normally gates in response to membrane tension, early studies...

The ongoing high precision E821 Brookhaven National Laboratory experiment on muon g22 is promising to probe a theory involving supersymmetry. We have studied the constraints on the minimal anomaly mediated supersymmetry breaking ~AMSB! model using the current data of muon g22 from Brookhaven. A scenario of seeing no deviation from the standard model is also considered, within a 2s limit of the ...

We report the draft 3.675-Mbp genome sequence of "Candidatus Halobonum tyrrellensis" strain G22, a novel halophilic archaeon isolated from the surface hypersaline waters of Lake Tyrrell, Australia. The availability of the first genome from the "Candidatus Halobonum" genus provides a new genomic resource for the comparative genomic analysis of halophilic Archaea.

Wheat is a globally significant cereal crop crucial for ensuring food security. Plant breeders strive to enhance yield potential by developing optimized and stable genotypes. In Pakistan, an agricultural country facing security challenges, annual multi-environment trials (MET)’s systematic conduct transpire across various research stations in Punjab province. Precise data analysis of these para...

Ever since the seminal work by Rothschild and Stiglitz (1976) on competitive insurance markets under adverse selection the equilibrium-non-existence problem has been one of the major puzzles in insurance economics. We extend the original analysis by considering firms which face capacity constraints, which might be due to limited capital. We show that under mild assumptions a pure strategy equil...