the activities of 4-aminobutyric-2-oxoglutaric acid transaminase (gaba-t) and succinate semialdehyde dehydrogenase (ssadh) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (cck-x)and/or caerulein (cln). gaba transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of gab a-t, succinate semialdehyde...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

Background and purpose Executive function impairment, a slight but noticeable cognitive deficit in mild impairment (MCI) patients, is influenced by gamma-aminobutyric acid (GABA) levels. Reduced accompanied thinning of the cerebral cortex, which has higher GABA levels than white matter. However, relationships among levels, cortical thickness, executive MCI patients have not yet been elucidated....

Lactic acid bacteria have become popular because of their γ-aminobutyric (GABA)-producing ability. In the present study, we selected four Levilactobacillus brevis strains (MG5552, MG5405, MG5261, and MG5522) with GABA-producing ability from 33 isolated various fermented foods in South Korea. We evaluated using thin-layer chromatography determined GABA levels produced by each strain an amino ana...

Background: Neurotransmitter release is an essential link in cell communication of the nervous system. Many investigations have focused on gamma amino butyric acid (GABA)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. To bypass complications related to homo- and heterosynaptic modulation and to avoid indirect interpret...

Introduction: Compounds which are used to treat organophosphate (OP) poisoning are not able to fully alleviate long lasting effects. They are mainly used to antagonize cholinergic effects of Ops. However, non-cholinergic effects, such as interference with different neurotransmitter systems, especially GABA release and uptake, are recently attracting more attentions. We have tried to investi...

The contents of GABA, glutamine (Glu) and asparagine (Asp) acids as well as activities of glutamatdecarboxylase (GDK; CF 4.1.1.15) and 4-aminobutirat: 2-oxoglutarataminotransferase (GABA-T: CF 2.6.1.19) in brain cortex, cerebellum, brainstem and hypothalamus under impact of testosterone propionate at a dose of 5 mg/100 g of alive weight of adult albino male rats in spring and autumn were studie...

background: it has been suggested that organophosphates may inhibit gamma-aminobutyric acid (gaba) metabolism in synaptosomal preparations. in the present investigation, we have assessed the interaction between paraoxon and the gaba system at synaptic level.   methods: synaptosomes were prepared from male wistar rats (200-250 g). cerebral cortex was dissected and homogenized, then centrifuged a...