GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding five different proteins: the biosynthetic enzyme for GABA, the vesicular GABA tr...

The ρ 1 GABA receptor cloned from rat retina is down-modulated by protons. sensitivities of human and rat ρ 1 GABA receptors to extracellular pH.

background and objective: amygdala contains central nucleus which is the region rich of γ-aminobutyric acid (gaba-a) receptors and plays a key role in modulating behavior and sleep homeostasis. furthermore, dysfunction of amygdala probably contributes to anxiety and mood disorders. in this study, we evaluated the association between acute sleep deprivation (asd) and anxiety through gaba-a recep...

The non-classical, but frequently reported behavior of GABA(A) receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity...

This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs. A total of 24 lambs weaned at age of 50 days were divided into four block of six based on their BW, six lambs within a block were allocated to three pairs, which were then assigned randomly to three treatments with...

Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder....

GABAB receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABAB receptor forms part of larger signaling complexes, which enable the receptor to mediate multiple different effects within neurons. Here we report that GABAB receptors can physically associate with the potassium-chl...

objective(s) in this study we investigated the expression of gabaa receptor subunits during brain development. these receptors may change in the embryonic chick forebrain. materials and methodes the expression levels of four types of gabaa receptor gamma subunits (γ1, γ2, γ3 and γ4) were quantified in the embryonic chick forebrain at 32 hr, 3, 7, 14, and 20 days of incubation and day one after ...

The neurotransmitter gamma-aminobutyric acid (GABA) mediates inhibitory signaling in the brain via stimulation of both GABA(A) receptors (GABA(A)R), which are chloride-permeant ion channels, and GABA(B) receptors (GABA(B)R), which signal through coupling to G proteins. Here we report physical interactions between these two different classes of GABA receptor. Association of the GABA(B) receptor ...

Abstract The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA A receptor modulators was performed and is herein described. crucial step the involving handling unstable aminothiophenes managed via two different synthetic strategies delivering a set 8 target compounds. Graphical abstract