Schizophrenia is characterized by loss of brain volume, which may represent an ongoing pathophysiological process. This loss of brain volume may be explained by reduced neuropil rather than neuronal loss, suggesting abnormal synaptic plasticity and cortical microcircuitry. A possible mechanism is hypofunction of the NMDA-type of glutamate receptor, which reduces the excitation of inhibitory GAB...

background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their ?-aminobutyric acid-aminotransferase (GABA-AT) inhibition in-vivo anticonvulsant activity. Among all the synthesized derivatives, compound 7f was observed as most potent competitive inhibitor of GABA-AT (IC50 = 46.29 ± 3.19 µM, Ki 0.106 0.004 ?M). The acti...

background preliminary studies revealed that 4-aminobutyric acid (gaba) is a key and major inhibitory neurotransmitter in the brain. evidence from many animal studies and even some clinical studies indicate that gaba is responsible for regulating behavior and also plays an important role in brain functions. previous studies presented glutamic acid decarboxylase as a catalyst for the conversion ...

Lactiplantibacillus plantarum has been widely studied due to its beneficial effects on health such as protect against pathogens, enhance the immune system, or produce metabolites like γ-aminobutyric acid (GABA). The objective of this study was evaluation GABA-producer L. K16 isolated from kimchi. safety and probiotic characterisation strain performed by analysing carbohydrates fermentation, enz...

Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) glutamate play an important role in (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional of transmitters inhibition during flexibility. Healthy...

Chile es uno de los países Latinoamérica que exhibe un mayor envejecimiento poblacional, por lo necesario visualizar distintas herramientas direccionen estilos vida saludables en esta etapa la trayectoria vital. Las Guías Alimentarias Basadas Alimentos (GABA) entregan recomendaciones permiten mejorar calidad personas mayores. Por anterior, el objetivo del estudio fue determinar nivel cumplim...

?-Aminobutyric acid (GABA) is a non-protein amino that accumulates in many plant species response to environmental stress. A number of reverse-genetic experiments and omics analyses have revealed positive relationships between GABA levels tolerance stresses. Furthermore, the application exogenous has been demonstrated effectively reduce ROS levels, enhance membrane stability modulate phytohormo...

objective(s):there is much evidence indicating that depression is influenced by the levels of neurotransmitters such as dopamine, gaba and adrenaline. the current study we designed to investigate the effect of exposure of pregnant rats to different colors on neurotransmitters level, as indicators of mood disorders in off springs. materials and methods:five groups of pregnant female wistar rats ...

The transmitter release from GABAergic synapses is thought to be calcium (Ca2+) dependent. The pharmacological modulation of Ca2+ currents in central GABAergic neurons may strongly affect GABA release from synaptic sites. The source of striatal GABA-containing synapses is intrinsic to the striatum and mainly originates from axon collaterals of projecting medium-spiny neurons. In order to charac...