This study was conducted to explore the effects of heat stress (HS) and γ-aminobutyric acid (GABA) on antioxidation in intestinal mucosa of Wenchang chickens. One-day-old male chickens were randomly divided into GABA and control (CK) groups after 15 days feeding. The chicken from GABA group fed with 0.2 ml GABA solution and the chicken from CK group fed with 0.2 ml normal saline daily. At the a...

BACKGROUND Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycem...

Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...

γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-...

glutamate decarboxylase enzyme produces γ-aminobutyric acid (gaba) in a non-reversible decarboxylation reaction of glutamate. gaba is a major inhibitory neurotransmitter of the brain and it is also present at high concentration in other organs such as pancreatic islets. gaba has effects on blood pressure, diabetes, inflammation, sleeplessness and depression. some bacteria such as lactobacillus ...

The hypothetical modulation by GABAergic neurons of yawning behavior in the rat was explored with GABA-active drugs. Gamma-acetylenic-GABA, a specific inhibitor of GABA-T, increases yawning frequency when injected at a dose of 7 mg/kg. Baclofen, a GABAB agonist (3 mg/kg), inhibits yawning completely; GABA antagonists, bicuculline and picrotoxin, at subconvulsant doses, also decrease yawning. Al...

The effects of gamma-hexachlorocyclohexane (gamma-HCH) and its alpha, beta and delta isomers on the gamma-aminobutyric acid (GABA) responses of human alpha1beta3gamma2S and alpha6beta3gamma2S GABA(A) receptors expressed in Xenopus oocytes were examined by conventional two-electrode voltage-clamp techniques. Gamma-HCH induced partial inhibition of EC50 GABA responses, whereas the alpha and delta...

Bhandage, A. K. 2016. Glutamate and GABA signalling components in the human brain and in immune cells. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1218. 81 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9558-9. Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous syst...

Several neurochemical and electrophysiological studies have shown that neuronal nicotinic receptors are desensitized by pretreatment with lower agonist concentrations than are required to activate the receptors, but the extent of desensitization and agonist concentration required to produce desensitization vary depending upon receptor subtype. Recently, we reported that nicotinic agonists will ...

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