s | 45 Methods: Gabapentin 10, 30mg/kg; diclofenac 5mg/kg(reference drug), vehicle(saline) were injected intraperitoneally before 100μl of 1% carrageenan administration into the right hind paws of the rats. Paw thickness was measured by a gauge calipers(Vernier Calipers) before (0th hour) and in every hour during 6 hours after induction of inflammation. Paw thickness of treated groups were comp...

Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and tramadol, but these are only partially effective when given alone. The aim of this study was to assess the antinociceptive interaction between both drugs using the isobolograph...

BACKGROUND AND PURPOSE The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. METHODS PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapentin treatment up to November 2015. FINDINGS This review included 26 studies...

BACKGROUND Neuropathic pain is characterized by hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to NSAIDs or even opioids. Gabapentin, a GABA analogue, was originally developed to treat epilepsy. Accumulating clinical evidence supports the effectiveness of this drug for diverse neuropathic pain. In this study, we showed that the anti-allodynic effect of...

s | 45 Methods: Gabapentin 10, 30mg/kg; diclofenac 5mg/kg(reference drug), vehicle(saline) were injected intraperitoneally before 100μl of 1% carrageenan administration into the right hind paws of the rats. Paw thickness was measured by a gauge calipers(Vernier Calipers) before (0th hour) and in every hour during 6 hours after induction of inflammation. Paw thickness of treated groups were comp...

BACKGROUND Postoperative pain and opioid use are associated with postoperative delirium. We designed a single-center, randomized, placebo-controlled, parallel-arm, double-blinded trial to determine whether perioperative administration of gabapentin reduced postoperative delirium after noncardiac surgery. METHODS Patients were randomly assigned to receive placebo (N = 347) or gabapentin 900 mg...

PURPOSE OF REVIEW Gabapentin and pregabalin bind to the alpha-2-delta calcium channel subunit and represent a novel analgesic drug class. The evidence base supporting their use for chronic neuropathic and early postsurgical pain is reviewed. RECENT FINDINGS Multiple, large, high-quality trials have demonstrated the safety and efficacy of gabapentin and pregabalin in neuropathic pain. Treatmen...

Gabapentin, a drug used to treat neuropathic pain, was evaluated in models of acute nociceptive pain, in instances of haloperidol-induced catalepsy, carrageenan-induced paw edema, gastric lesions caused by indomethacin or ethanol, and gastric acid secretion in rats. Reaction time in a hot plate assay was delayed by gabapentin. The antinociceptive effect of the drug was produced with a dose of 1...

BACKGROUND Uraemic pruritus is a common and distressing symptom in patients on haemodialysis for chronic renal failure. Gabapentin is an anticonvulsant that alleviates neuropathic pain. We conducted a double-blind, placebo-controlled, crossover study to assess its effectiveness against renal itch. METHODS We enrolled in the trial 25 adult patients on haemodialysis who were asked to daily reco...

INTRODUCTION Hot flashes represent a significant problem in men undergoing androgen deprivation therapy. MATERIALS AND METHODS Via a prospective, double-blind, placebo-controlled clinical trial, men with hot flashes, on a stable androgen deprivation therapy program for prostate cancer, received a placebo or gabapentin at target doses of 300, 600, or 900 mg/day. Hot flash frequencies and sever...