Abstract Our previous research has shown that galanin plays an antinociceptive effect via binding to receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 galanin-induced NAc neuropathic pain rats. The chronic constriction injury sciatic nerve (CCI) was used mimic model. hind paw withdrawal latency (HWL) thermal stimulation and threshold (HWT) mechanical w...

Single ligature nerve constriction (SLNC) is a newly developed animal model for the study of neuropathic pain. SLNC of the rat sciatic nerve induces pain-related behaviors, as well as changes in the expression of neuropeptide tyrosine and the Y(1) receptor in lumbar dorsal root ganglia (DRGs) and spinal cord. In the present study, we have analyzed the expression of another neuropeptide, galanin...

Galanin and its receptors have been shown to be expressed in undifferentiated mouse embryonic stem (ES) cells through transcriptome and proteomic analyses. Although transcriptional regulation of galanin has been extensively studied, the regulatory proteins that mediate galanin expression in mouse ES cells have not yet been determined. Through sequence alignments, we have found a high degree of ...

Selective serotonin reuptake inhibitors, such as fluoxetine (FLX), are the most commonly used drugs in the treatment of major depression. However, there is a limited understanding of their molecular mechanism of action. Although the acute effect of selective serotonin reuptake inhibitors in elevating synaptic serotonin concentrations is well known, the clinical amelioration of depressive sympto...

The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related afferents and a strategic site for the modulation of the cough reflex. The similarities between the characteristics of central processing of nociceptive and cough-related inputs led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, could also be involved in the regulation of t...

Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat...

Activation of hepatic nerves increases both hepatic glucose production (HGP) and hepatic arterial vasoconstriction, the latter best described by a decrease of hepatic arterial conductance (HAC). Because activation of canine hepatic nerves releases the neuropeptides galanin and neuropeptide Y (NPY) as well as the classical neurotransmitter norepinephrine (NE), we sought to determine the relative...

This study investigated the effects of five levels of galanin on plasma concentrations of growth hormone , Triiodothyronine, thyroxine and milk fat in dairy goat breed was sannan .15 breeds of dairy goats sannan all about the same age and weight were selected for this study and were randomly divided into five treatments ( three replicates per treatment ). Levels of the hormone injection of gala...

This study investigated the effects of five levels of galanin on plasma concentrations of growth hormone , Triiodothyronine, thyroxine and milk fat in dairy goat breed was sannan .15 breeds of dairy goats sannan all about the same age and weight were selected for this study and were randomly divided into five treatments ( three replicates per treatment ). Levels of the hormone injection of gala...

Galanin mRNA levels in GnRH neurons increase in association with a steroid-induced LH surge in female rats. Both the steroid-induced LH surge and the concomitant increase of galanin mRNA in GnRH neurons are blocked by non-specific inhibition of central nervous system activity imposed by pentobarbital and specific central alpha-adrenergic receptor blockade. Based on these observations, we hypoth...