Electrospun membranes of polycaprolactone are widely used for biomedical applications like wound dressings and tissue engineering scaffolds. It is important to sterilize this material using the most accepted method, the gamma irradiation. In this study, we have evaluated the sterilizability of electrospun polycaprolactone membranes with gamma radiation of varying doses. The irradiated materials...

This research work aimed to enhance the concentration of some bioactive compounds in culantro (Eryngium foetidum L.) plantlets through gamma irradiation (0.0, 10.0, 20.0 and 40.0 Gy range) treatments. Gamma irradiation at 40.0 Gy significantly stimulated total phenolic, flavonoids, tannin and saponin contents. The effect of irradiation on antioxidant properties of culantro extracts was investig...

Background: During radiation therapy, stromal cells surrounding the tumor (e.g mesenchymal stem cells) may affect the treatment outcomes. We aimed to investigate the effects of gamma radiation on the mRNA expression of cytokines, DNA damage and population doubling time (PDT) of adipose-derived mesenchymal stem cells (ASCs). Material and methods: ASCs were enzymatically extracted from breast tis...

PURPOSE OF THE STUDY Each method of sterilisation has some effect on the structure and properties of UHMWPE and thus also on joint replacement longevity. This study was designed to compare, using objective methods of measurement, several kinds of sterilisation and to recommend the one which has the best prospect for making joint replacements last longer. MATERIAL AND METHODS Two groups of UHM...

background: lymphocytes of fanconi anemia (fa) show an increased sensitivity to the alkylating agents such as mitomycin c (mmc), but their responses to gamma-irradiation is controversial. the extent of dna damage in leukocytes of fa patients following irradiation and mmc treatment was studied at cellular and single chromosome level. methods: dna damage induced by gamma-rays and mmc was measured...

The present study was carried out to evaluate the radioprotective role of lycopene on chromosomal aberrations (CAs) induced by gamma (gamma) radiation in human lymphocytes. For this purpose, we used in vitro dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, tricentric, acentric, fragment and ring. Mitotic ...

Gold nanoparticles are promising as a kind of novel radiosensitizer in radiotherapy. If gold nanoparticles are shown to have good irradiation stability and biocompatibility, they would play an important role in radiotherapy. In this work, we investigated irradiation effects of gold nanoparticles under 2-10 kR gamma irradiation and cytotoxicity of gold nanoparticles with human K562 cells by usin...

Exposure of astronauts in space to radiation during weightlessness may contribute to subsequent bone loss. Gamma irradiation of postpubertal mice rapidly increases the number of bone-resorbing osteoclasts and causes bone loss in cancellous tissue; similar changes occur in skeletal diseases associated with oxidative stress. Therefore, we hypothesized that increased oxidative stress mediates radi...

To investigate the effect of gamma irradiation on the nutritional quality of maize and sorghum grains, packs were exposed to doses of 0 and 2 kGy in a 60 Co package irradiator. Irradiated and nonirradiated samples were stored at refrigeration temperatures. Proximate composition, minerals content, minerals bio-availability, tannins content, phytic acid content, protein fractions and in vitro pro...

Ultra-high-molecular-weight polyethylene (UHMWPE) components for total joint replacement generate wear particles which cause adverse biological tissue reactions leading to osteolysis and loosening. Sterilisation of UHMWPE components by gamma irradiation in air causes chain scissions which initiate a long-term oxidative process that degrades the chemical and mechanical properties of the polyethy...