Background To evaluate the efficacy and safety of an extemporaneous preparation of 2% ganciclovir topical eye drops in cytomegalovirus (CMV) anterior uveitis because many studies have confirmed the benefits of topical ganciclovir in varying concentrations. Design The study employed a retrospective cohort design. Methods This study enrolled 11 eyes (11 patients) with CMV anterior uveitis. Al...

BACKGROUND Cytomegalovirus (CMV) disease is one of the major challenges of lung transplantation that may determine outcome. The benefits of ganciclovir prophylaxis seem indisputable, but no consensus has been reached on the optimal duration of therapy. Results with different protocols suggest that efficacy is related to the duration of treatment. MATERIALS AND METHODS To evaluate the addition...

conclusion we concluded that cmv is the most common cause of intrauterine infection in infants aged less than 6 months as compared to the healthy ones. we prefer, at least in our country, to consider seropositive (cmv-igm) infants suspected of intrauterine infection (less than 6 months) as congenital form. to arrest the natural progression of congenital cmv, we recommend prolonged course of ora...

Study sample There were 22 patients in the acyclovir group compared with 33 in the ganciclovir group. The mean age of patients in both groups was 40 years of age and 32% of patients were female in the acyclovir group compared with 48% of the ganciclovir group. Similarly 27% and 35% of patients in the two groups respectively received PA transplants. Power calculations were not used to determine ...

Department of Neurology and Institute of Radiology, Medical School, University of São Paulo, São Paulo SP, Brazil. A 19-year-old previously healthy boy was admitted with a ten-day history of rapidly progressive urinary retention, constipation, ascending hypoesthesia up to the thoracic level and gait instability. On physical examination, he presented fever, tetraparesis, brisk reflexes, multidir...

Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in patients with acquired immunodeficiency syndrome. In a prospective study of 210 patients with CMV retinitis, 26 were identified as having either a phenotypic or a genotypic ganciclovir-resistant isolate from either blood or urine cultures. For blood culture isolates with an IC(50) >6.0 microm for ganciclovir, t...

The in vitro antihepadnavirus activities of the purine nucleoside analogs ganciclovir (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine) and penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; BRL 39123] were compared in primary duck hepatocyte cultures congenitally infected with the duck hepatitis B virus (DHBV). Both compounds inhibited DHBV DNA replication to a comparable extent dur...

BAY38-4766 and BAY43-9695 are nonnucleosidic compounds with activities against human cytomegalovirus (HCMV). Two phenotypic assays were used to determine the drug susceptibilities of 36 HCMV clinical isolates to the BAY compounds and ganciclovir. Using either assay, both BAY compounds at a concentration of approximately 1 microM inhibited the replication of all 36 HCMV clinical isolates, includ...

Chemotherapy is mostly effective in helping cancer patients but invariably some cells will mutate to become more fit against chemotherapeutic agents. We build upon previous work that focuses on transfecting tumor cells via a delivery virus. The transfected cells then become both chemoresistant and sensitive to ganciclovir, which is an acyclic nucleotide antiviral agent. A positive selection pha...

1. Boeckh M, Gooley T, Myerson D, Cunningham T, Schoch GH, Bowden RA: Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplant—A randomized double-blind study. Blood 88:4063, 1996 2. Einsele H, Ehninger G, Hebart H, Wittkowsky KM, Schuler U, Jahn G, Mackes P, Hertes M, Klingebiel T, Löffler J, Wagner S, Müller ...