neovascularization of the normally avascular cornea was associated with a notable increase in the expression of the major pro-angiogenic factors, inflammatory cytokines and proteases. the data supporting a causal role for vascular endothelial growth factor (vegf), inflammatory cytokines and matrix metalloproteinase (mmps) are extensive. anti-angiogenic/anti-inflammatory therapy is considered as...

The chitin was isolated from the Ganoderma lucidum submerged cultures mycelium as potential source of chitin under biotechnological processes. The extraction of chitin was carried out through 5 different assays which involved mainly three phases: pulverization of the mushroom, deproteinization of the mycelia with NaOH solution, and a process of decolorization with potassium permanganate and oxa...

background: the water-soluble extract of ganoderma lucidum (reishi) has been used as an immunomodulator to stimulate spleen cells proliferation and cytokine expression. objective: to investigate the effect of ganoderma lucidum (g. lucidum) on cytokine production by mice peritoneal macrophages. methods: mice peritoneal macrophages were prepared by intra-peritoneal injection of 5 ml cold pbs. per...

Background: The water-soluble extract of Ganoderma lucidum (Reishi) has been used as an immunomodulator to stimulate spleen cells proliferation and cytokine expression. Objective: To investigate the effect of Ganoderma lucidum (G. lucidum) on cytokine production by mice peritoneal macrophages. Methods: Mice peritoneal macrophages were prepared by intra-peritoneal injection of 5 ml cold PBS. Per...

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line H...

The ability of Ganoderma to produce extracellular enzymes, including β-glucosidase, cellulase, avicelase, pectinase, xylanase, protease, amylase, and ligninase was tested in chromogenic media. β-glucosidase showed the highest activity, among the eight tested enzymes. In particular, Ganoderma neo-japonicum showed significantly stronger activity for β-glucosidase than that of the other enzymes. T...

Introduction Ganoderma lucidum, an oriental fungus has a long history of use for promoting health and longevity in China, Japan, and other Asian countries. In China, G. lucidum is called lingzhi, whereas in Japan the name for the Ganodermataceae family is reishi. Ganoderma has a unique double walled basidiospore with a shining skin. Some of the active compounds identified in the cell wall of th...