Background—Cholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated. Aims—To determine the eVects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility. Methods—Ten normal subjects underwent three studies each, using simult...

The aims of the present study were to compare the gastric emptying of dry matter (DM) and liquids during the feeding period with that following meal consumption, to clarify the relationship between feeding and gastric emptying, and to investigate how gastric emptying changes in growing animals. The studies were performed in pigs fitted with a gastric cannula and fed on a normal finely ground so...

Moran, Timothy H., Susan Knipp, and Gary J. Schwartz. Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1282–R1290, 1999.—To study the dynamics of liquid gastric emptying in rhesus monkeys under conditions that simulated gastric fill during a meal, we measured the gas...

BACKGROUND Cholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated. AIMS To determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility. METHODS Ten normal subjects underwent three studies each, using s...

During the early stages of diabetes, gastric emptying is often accelerated, rather than delayed. The mechanism of accelerated gastric emptying in diabetes has not been fully studied. A recent study showed that plasma ghrelin levels were elevated in diabetes. As postprandial antropyloric coordination plays an important role in mediating solid gastric emptying, we hypothesize that the elevated pl...

Digestive tract motility patterns are closely related to the pathophysiology of functional gastrointestinal diseases (FGID), and these patterns differ markedly between the interdigestive period and the postprandial period. The characteristic motility pattern in the interdigestive period is so-called interdigestive migrating contraction (IMC). IMCs have a housekeeping role in the intestinal trac...

PURPOSE To evaluate a magnetic resonance (MR) imaging method for simultaneous assessment of gastric emptying and motility. MATERIALS AND METHODS Gastric emptying and motility were measured in nine volunteers after ingestion of a liquid meal. A specially designed MR imaging protocol was used that allowed simultaneous assessment of gastric emptying (spatial resolution, 1.5 mm; corrected for gas...

The oral disposition index, the product of the early insulin secretory response during an oral glucose tolerance test and insulin sensitivity, is used widely for both the prediction of, and evaluation of the response to interventions, in type 2 diabetes. Gastric emptying, which determines small intestinal exposure of nutrients, modulates postprandial glycemia. The aim of this study was to deter...

Glucagon-like peptide-1(7-36)-amide (GLP-1) is postulated to act as a hormonal signal from gut to brain to inhibit food intake and gastric emptying. A mixed-nutrient meal produces a 2 to 3-h increase in plasma GLP-1. We determined the effects of intravenous infusions of GLP-1 on food intake, sham feeding, and gastric emptying in rats to assess whether GLP-1 inhibits food intake, in part, by slo...

To support decision-making around diet selection choices to manage glycemia following a meal, a novel mechanistic model of intermittent gastric emptying and plasma glucose-insulin dynamics was developed. Model development was guided by postprandial timecourses of plasma glucose, insulin and the gastric emptying marker acetaminophen in infant calves fed meals of 2 or 4 L milk replacer. Assigning...