Autophagy is a bulk protein and organelle degradation process essential for cell maintenance and viability. Microtubule-associated protein 1 light chain 3 (LC3), the mammalian homologue of yeast Atg8, is involved in autophagosome formation during autophagy. The aim of this study was to investigate LC3 expression in gastrointestinal cancers to elucidate the role of autophagy in human cancer deve...

Immune checkpoint inhibitors have revolutionized the management of mismatch repair-deficient (MMR-D)/microsatellite instability-high (MSI-H) gastrointestinal cancers, particularly colorectal cancer. Cancers with MMR-D/MSI-H genotype often carry a higher tumor mutation burden frameshift alterations, leading to increased mutation-associated neoantigen (MANA) generation. The dramatic response seen...

Worldwide, the demand for natural and synthetic sweeteners in food industry as an alternative to refined sugar is increasing. This has prompted more research be conducted estimate its safety effects on health. The gut microbiome critical metabolizing selected which might affect overall Recently, studies have evaluated relationship between microbiome. review summarizes current knowledge regardin...