Although giant cell tumor of bone (GCT) is characterized by the extensive multinucleated giant cells among mononuclear stromal cells, proliferation of these cells and multinucleation are not without limit in certain cases. Few studies on oncogenesis of GCT have focused on the negative growth control, including growth arrest and apoptosis. The purpose of this study was to investigate the mechani...

The granular cell tumor (GCT) is an uncommon neoplasm, with slow progression, usually benign, that can be found in any organ. The most common region for GCT involvement is in the head and neck. Laryngeal involvement is uncommon and accounts for 6 to 10% of all cases reported. Among the major theories of origin and based on the strongest evidence, the most accepted one is that the tumor stems fr...

BACKGROUND About 3-5% of all patients with testicular germ cell tumour (GCT) develop a contralateral cancer, the majority of which arise within 10-15 years. Little is known about the risk of second GCTs after more than two decades. Here we present 3 cases with very late presenting contralateral GCT and provide a summary of similar cases reported previously. CASE PRESENTATIONS (1) This white C...

Primary intracranial germ cell tumor (GCT) is a rare tumor that generally occurs due to developmental anomaly. Although intracranial GCT is sensitive to treatment, a high recurrence rate, treatment-related long-term complications and the heterogeneity of this tumor group make treatment complicated. Moreover, because of its location, hydrocephalus and visual field defect, functional disturbance ...

NAD+-isocitrate dehydrogenase (NAD+-ICDH) is one of three enzymes which catalyse the oxidation of threo-Ds-isocitrate to oxoglutarate and carbon dioxide in eukaryotic cells, the other two enzymes being the cytoplasmic and mitochondrial forms of NADP+-isocitrate dehydrogenase (NADP+-ICDH). NAD+ICDH is located within mitochondria and is a component of the citrate cycle. Although mitochondria from...

The purpose of this study was to assess the reproducibility (test-retest reliability and agreement) and concurrent validity of the Myotest for measuring step frequency (SF) and ground contact time (GCT) in recreational runners. Based on a within-subjects design (test and retest), SF and GCT of 14 participants (11 males, 3 females) were measured at three different running speeds with the Myotest...

Giant cell tumor (GCT) of bone is an aggressive skeletal tumor characterized by localized bone resorption. MicroRNA-16-5p (miR-16-5p) has been reported to be downregulated in lesions of patients with GCT, but little is known about its role in GCT. To explore the underlying function of miR-16-5p in GCT, we first detected its expression in patients with GCT. The results showed that osteoclast for...

BACKGROUND Gestational diabetes mellitus (GDM) complicates 3-7% of all pregnancies and fetomaternal outcomes are strongly related to early diagnosis of GDM. The aim of this study was to determine the impact of risk factors in the prediction of an abnormal glucose challenge test (GCT). MATERIALS AND METHODS This was a prospective study conducted during 2009-2010 in two prenatal clinics in Rey,...

Driver mutations in the two histone 3.3 (H3.3) genes, H3F3A and H3F3B, were recently identified by whole genome sequencing in 95% of chondroblastoma (CB) and by targeted gene sequencing in 92% of giant cell tumour of bone (GCT). Given the high prevalence of these driver mutations, it may be possible to utilise these alterations as diagnostic adjuncts in clinical practice. Here, we explored the ...

Introduction. Giant cell tumors (GCTs) of bone are known for their local aggressiveness and high recurrence rate. There are rare cases of multicentric GCT and most are synchronous. We herein review metachronous multicentric GCT reported in the literature. Material and Methods. A MEDLINE, Cochrane, and Google Scholar search was done to collect all cases of multicentric metachronous GCT specifyin...