A marker-assisted background selection (MABS)-based gene introgression approach in wheat (Triticum aestivum L.) was optimized, where 97% or more of a recurrent parent genome (RPG) can be recovered in just two backcross (BC) generations. A four-step MABS method was developed based on 'Plabsim' computer simulations and wheat genome structure information. During empirical optimization of this meth...

hepatitis delta virus (hdv) infection results in more severe and even fulminant form of hepatitis b in co-infected cases. this study was designed to estimate the prevalence of anti-hdv positivity and the associated risk factors in patients with chronic hepatitis b virus infection in zahedan (iran). in this cross-sectional study a total of 440 consecutive patients with chronic hepatitis b virus ...

introduction : staphylococcus aureus colonization has been recognized as one of the most important risk factors for subsequent infections with this microorganism. in this study, we intended to identify all patients who were mrsa-positive upon admission and compare the prevalence of mrsa colonization on different days of study admitted in imam reza hospital in mashhad, iran. methods : this cross...

how to cite this article: boroujerdi r, shariati m, naddafnia h, rezaei h. small duplication of hprt 1 gene may be causative for lesh- nyhan disease in iranian patients. iran j child neurol. 2015 winter;9(1):103-106. abstract deficiency of hypoxanthine-guanine phosphoribosyltransferase (hgprt) is a rare inborn error of purine metabolism and is characterized by uric acid overproduction along wit...

Champagne coat color in horses is controlled by a single, autosomal-dominant gene (CH). The phenotype produced by this gene is valued by many horse breeders, but can be difficult to distinguish from the effect produced by the Cream coat color dilution gene (CR). Three sires and their families segregating for CH were tested by genome scanning with microsatellite markers. The CH gene was mapped w...

Thiamin is essential for normal function of pancreatic acinar cells, and its deficiency leads to a reduction in pancreatic digestive enzymes. We have recently shown that thiamin uptake by rat pancreatic acinar cells is carrier-mediated and that both thiamin transporter (THTR)-1 and THTR-2 are expressed in these cells; little, however, is known about the relative contribution of these transporte...

in this study, feasibility of upgrading and retrofitting municipal wastewater treatment plantswas investigated at laboratory scale using moving bed biofilm reactor (mbbr) process. for this purpose,an aerobic pilot was operated for nearly one year in different conditions, in which a moving bed carrier with aspecific biofilm surface area of 500 m2/m3 and a filling rate of 60% was utilized. system...

This study determines the value of linkage analysis using six RFLP markers for carrier detection and prenatal diagnosis in familial DMD/BMD cases and their family members for the first time in the Iranian population. We studied the dystrophin gene in 33 unrelated patients with clinical diagnosis of DMD or BMD. Subsequently, we determined the rate of heterozygosity for six intragenic RFLP marker...

The fragile X syndrome is the most frequent cause of inherited mental retardation. It is caused by a dynamic mutation: the progressive expansion of polymorphic (CGG)n trinucleotide repeats located in the promoter region of the FMRI gene at Xq27.3. The cloning of the FMRI gene and the elucidation of the molecular basis of the fragile X syndrome is of great importance for the diagnosis and unders...